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QuickView for Gcnf (gene)


Gene Symbol:
NR6A1 Homo sapiens Homo sapiens
Full name:
nuclear receptor subfamily 6 group A member 1
Synonyms:
CT150, GCNF, GCNF1, NR61, RTR, hGCNF, hRTR, nuclear receptor subfamily 6 group A member 1, germ cell nuclear factor variant 1, retinoic acid receptor-related testis-associated receptor, retinoid receptor-related testis-specific receptor
Genomic Location:
Chr 9: 126324524-126573397
Description:
This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Danio rerio Pan troglodytes Bos taurus Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
TGGAAA_NFAT_Q4_01 POU6F1_01 SMTTTTGT_UNKNOWN OCT1_B DR3_Q4 TAL1ALPHAE47_01 STAT1_02 OCT1_04 TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D TGANNYRGCA_TCF11MAFG_01
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 9
9q33.3





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nuclear receptor activity | cation binding | transcription factor activity, direct ligand regulated sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | steroid hormone receptor activity | RNA polymerase II regulatory region DNA binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | identical protein binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | protein homodimerization activity | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transition metal ion binding | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | DNA-templated transcription, initiation | positive regulation of macromolecule biosynthetic process | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | male gamete generation | hormone-mediated signaling pathway | positive regulation of cellular biosynthetic process | cellular process | nuclear receptor activity | transcription factor activity, direct ligand regulated sequence-specific DNA binding | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | gamete generation | regulation of cellular process | cellular response to lipid | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | response to stimulus | cellular nitrogen compound biosynthetic process | reproduction | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | steroid hormone receptor activity | steroid hormone mediated signaling pathway | cellular biosynthetic process | regulation of nucleic acid-templated transcription | cellular response to hormone stimulus | nitrogen compound metabolic process | reproductive process | regulation of gene expression | response to lipid | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | cell proliferation | biosynthetic process | aromatic compound biosynthetic process | cell communication | regulation of cellular metabolic process | regulation of RNA metabolic process | multicellular organism reproduction | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | response to organic substance | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | cellular response to steroid hormone stimulus | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | intracellular receptor signaling pathway | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cellular macromolecule biosynthetic process | spermatogenesis | intracellular steroid hormone receptor signaling pathway | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | response to steroid hormone | sexual reproduction | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | transcription factor complex | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular