QuickView for Glud1 (gene)
- Gene Symbol:
- GLUD1
Homo sapiens - Full name:
- glutamate dehydrogenase 1
- Synonyms:
- GDH, GDH1, GLUD, glutamate dehydrogenase 1, mitochondrial, epididymis tissue sperm binding protein Li 18mP, glutamate dehydrogenase (NAD(P)+)
- Genomic Location:
- Chr 10: 88800223-88844603
- Description:
-
This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in ...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
10q23.2
| Transcripts Names |
|---|
| NM_005271 |
| NM_001318902 |
| NM_001318901 |
| NM_001318904 |
| NM_001318900 |
| NM_001318906 |
| NM_001318905 |
GO Molecular Function
ADP binding | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor | guanyl ribonucleotide binding | cofactor binding | ribonucleoside binding | leucine binding | cation binding | carboxylic acid binding | ribonucleotide binding | nucleotide binding | coenzyme binding | carbohydrate derivative binding | glutamate dehydrogenase (NAD+) activity | NAD+ binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | amino acid binding | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | purine nucleoside binding | glutamate dehydrogenase [NAD(P)+] activity | purine ribonucleoside triphosphate binding | protein binding | NAD binding | GTP binding | oxidoreductase activity, acting on the CH-NH2 group of donors | nucleoside binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | organic acid binding | heterocyclic compound binding | oxidoreductase activity | guanyl nucleotide binding | small molecule binding
GO Biological Process
brain development | regulation of localization | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor | nervous system development | regulation of peptide hormone secretion | positive regulation of protein secretion | cellular amino acid catabolic process | cellular process | organic substance catabolic process | dicarboxylic acid metabolic process | cellular amino acid metabolic process | regulation of cellular process | catabolic process | glutamate biosynthetic process | head development | regulation of peptide secretion | regulation of insulin secretion | dicarboxylic acid catabolic process | carboxylic acid catabolic process | cellular amino acid biosynthetic process | glutamate dehydrogenase (NAD+) activity | midbrain development | positive regulation of hormone secretion | regulation of protein transport | regulation of peptide transport | cellular biosynthetic process | positive regulation of peptide secretion | system development | nitrogen compound metabolic process | multicellular organism development | regulation of hormone levels | regulation of hormone secretion | glutamate metabolic process | positive regulation of secretion | small molecule metabolic process | substantia nigra development | biosynthetic process | glutamate catabolic process | glutamate dehydrogenase [NAD(P)+] activity | positive regulation of establishment of protein localization | positive regulation of transport | positive regulation of peptide hormone secretion | carboxylic acid metabolic process | regulation of establishment of protein localization | positive regulation of insulin secretion | tricarboxylic acid metabolic process | anatomical structure development | glutamine metabolic process | metabolic process | oxidation-reduction process | regulation of secretion | organic substance metabolic process | oxidoreductase activity, acting on the CH-NH2 group of donors | animal organ development | regulation of protein secretion | positive regulation of protein transport | organonitrogen compound catabolic process | regulation of cell communication | organic acid metabolic process | developmental process | regulation of transport | central nervous system development | cellular metabolic process | regulation of protein localization | oxidoreductase activity | positive regulation of signaling | neural nucleus development | regulation of signaling | multicellular organismal process
GO Cellular Component
mitochondrial matrix | intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | organelle | membrane-enclosed lumen | intracellular
