QuickView for Gpa1 (gene)
- Gene Symbol:
- GPA1
Saccharomyces cerevisiae - Full name:
- GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome
- Synonyms:
- CDC70, DAC1, GPA1, SCG1, YHR005C
- Genomic Location:
- Chr VIII: 113494-114912
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , C. elegans , Macaca mulatta , Schizosaccharomyces pombe , Bos taurus , Danio rerio , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
guanyl ribonucleotide binding | ribonucleoside binding | cation binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | hydrolase activity | G-protein beta/gamma-subunit complex binding | carbohydrate derivative binding | pyrophosphatase activity | catalytic activity | anion binding | nucleoside-triphosphatase activity | purine nucleotide binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | purine ribonucleoside triphosphate binding | protein binding | G-protein coupled receptor binding | G-protein beta-subunit binding | GTP binding | hydrolase activity, acting on acid anhydrides | nucleoside binding | purine ribonucleotide binding | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding
GO Biological Process
nucleus organization | regulation of intracellular protein transport | microtubule-based transport | regulation of cellular localization | intracellular signal transduction | regulation of localization | organelle fusion | establishment of localization | intracellular transport | microtubule-based process | cellular process | establishment of organelle localization | localization | karyogamy | adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion | response to pheromone | cellular response to pheromone | regulation of protein export from nucleus | establishment of localization in cell | cytoskeleton-dependent intracellular transport | regulation of cellular process | organelle localization | pheromone-dependent signal transduction involved in conjugation with cellular fusion | regulation of MAPK export from nucleus | cellular component organization | response to stimulus | regulation of cellular protein localization | organelle transport along microtubule | microtubule-based movement | reproduction | cellular localization | conjugation | regulation of protein transport | G-protein coupled receptor signaling pathway | regulation of peptide transport | regulation of intracellular transport | response to pheromone triggering conjugation with cellular fusion | reproductive process | regulation of signal transduction | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | karyogamy involved in conjugation with cellular fusion | inositol lipid-mediated signaling | conjugation with cellular fusion | nuclear migration | cell communication | regulation of nucleocytoplasmic transport | positive regulation of conjugation with cellular fusion | nucleus localization | regulation of establishment of protein localization | response to organic substance | signal transduction involved in positive regulation of conjugation with cellular fusion | nuclear migration involved in conjugation with cellular fusion | transport along microtubule | nuclear migration along microtubule | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | signaling | organelle organization | regulation of transport | cellular response to organic substance | regulation of protein localization | sexual reproduction | signal transduction | regulation of signaling
GO Cellular Component
heterotrimeric G-protein complex | cytoplasmic side of plasma membrane | catalytic complex | extrinsic component of membrane | organelle membrane | cytoplasmic vesicle | cell | cytoplasmic side of membrane | plasma membrane protein complex | extrinsic component of plasma membrane | cytoplasm | intracellular organelle | endosome membrane | protein-containing complex | endomembrane system | plasma membrane | extrinsic component of cytoplasmic side of plasma membrane | vesicle | endosome | membrane-bounded organelle | organelle | cell periphery | cytosol | intracellular vesicle | intracellular | membrane
