QuickView for HBG1 (gene)

Gene Symbol:

HBG1 Homo sapiens

Full name:

hemoglobin subunit gamma 1

Synonyms:

HBG-T2, HBGA, HBGR, HSGGL1, PRO2979, hemoglobin subunit gamma-1, A-gamma globin, gamma A hemoglobin, gamma globin, gamma-1-globin, hb F Agamma, hemoglobin gamma-1 chain, hemoglobin gamma-a chain, hemoglobin, gamma A, hemoglobin, gamma, regulator of

Genomic Location:

Chr 11: 5226078-5227663

Description:

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. ...

View Full Description

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Cytogenetic Map:

11p15.4

search → result