QuickView for HBO1 (gene)

Gene Symbol:

KAT7 Homo sapiens

Full name:

lysine acetyltransferase 7

Synonyms:

HBO1, HBOA, MYST2, ZC2HC7, histone acetyltransferase KAT7, K(lysine) acetyltransferase 7, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2, MYST histone acetyltransferase 2, histone acetyltransferase MYST2, histone acetyltransferase binding to ORC1

Genomic Location:

Chr 17: 45221070-45261457

Description:

The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be ...

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The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  GCGSCMNTTT_UNKNOWN ,  GATA1_01 ,  TCANNTGAY_SREBP1_01 ,  NGFIC_01 ,  NFY_C ,  GTACTGT_MIR101 ,  GCCATNTTG_YY1_Q6 ,  NFKAPPAB65_01 ,  TATAAA_TATA_01 ,  SREBP1_01 ,  GTGACGY_E4F1_Q6 ,  GCTCTTG_MIR335 ,  CAGGTG_E12_Q6 ,  TGCGCANK_UNKNOWN ,  CDPCR1_01 ,  GGGCGGR_SP1_Q6 ,  GCM_Q2 ,  ACTGCAG_MIR173P ,  AP2_Q3 ,  CAGTCAC_MIR134 ,  RNGTGGGC_UNKNOWN ,  GTGCCTT_MIR506 ,  AP2_Q6 ,  CEBP_Q3 ,  TTGTTT_FOXO4_01 ,  SCGGAAGY_ELK1_02 ,  GAGCCAG_MIR149 ,  ATAACCT_MIR154 ,  CREL_01 ,  CCCNNNNNNAAGWT_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  EGR1_01 ,  TBP_01 ,  RCGCANGCGY_NRF1_Q6 ,  ELK1_02 ,  TCCCCAC_MIR491 ,  YNGTTNNNATT_UNKNOWN ,  ACACTAC_MIR1423P ,  GGGNNTTTCC_NFKB_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-134 ,  Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-491

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Cytogenetic Map:

17q21.33

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