QuickView for HCST (gene)

Gene Symbol:

HCST Homo sapiens

Full name:

hematopoietic cell signal transducer

Synonyms:

DAP10, KAP10, PIK3AP, hematopoietic cell signal transducer, DNAX-activation protein 10, kinase assoc pro of ~10kDa, kinase assoc protein, membrane protein DAP10, phosphoinositide-3-kinase adaptor protein, transmembrane adapter protein KAP10

Genomic Location:

Chr 19: 41085222-41087013

Description:

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways thro...

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This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ETS_Q4 ,  ZIC1_01 ,  RYTTCCTG_ETS2_B ,  ATF4_Q2 ,  NFKAPPAB_01 ,  GGGCGGR_SP1_Q6 ,  CCCNNGGGAR_OLF1_01 ,  GCM_Q2 ,  AP2_Q6 ,  CETS1P54_01 ,  IK2_01 ,  IK3_01 ,  CREL_01

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Cytogenetic Map:

19q13.12

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