QuickView for HDAC2 (gene)
- Gene Symbol:
- HDAC2
Homo sapiens - Full name:
- histone deacetylase 2
- Synonyms:
- HD2, RPD3, YAF1, histone deacetylase 2, YY1-associated factor 1, transcriptional regulator homolog RPD3
- Genomic Location:
- Chr 6: 114364019-114399047
- Description:
-
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many differ...
- Orthologs:
- Mus musculus , Rattus norvegicus , C. elegans , Macaca mulatta , Gallus gallus , Bos taurus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
6q21
GO Molecular Function
sequence-specific DNA binding | NF-kappaB binding | transcription regulatory region DNA binding | enhancer binding | repressing transcription factor binding | nucleosome binding | histone deacetylase activity (H3-K14 specific) | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | protein-containing complex binding | NAD-dependent histone deacetylase activity (H3-K14 specific) | hydrolase activity | protein deacetylase activity | catalytic activity | chromatin binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | NAD-dependent protein deacetylase activity | enhancer sequence-specific DNA binding | histone deacetylase activity | RNA polymerase II repressing transcription factor binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | promoter-specific chromatin binding | nucleosomal DNA binding | organic cyclic compound binding | NAD-dependent histone deacetylase activity | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcription factor binding | chromatin DNA binding | RNA polymerase II transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | deacetylase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | heat shock protein binding | histone deacetylase binding | heterocyclic compound binding | RNA binding
GO Biological Process
RNA metabolic process | limb development | molting cycle | positive regulation of macromolecule biosynthetic process | regulation of neurogenesis | ectodermal placode formation | response to lipopolysaccharide | regulation of cell development | positive regulation of collagen metabolic process | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | eye development | response to dopamine | negative regulation of cellular process | positive regulation of developmental process | negative regulation of RNA biosynthetic process | embryonic appendage morphogenesis | histone modification | cell differentiation | negative regulation of dendrite development | nervous system development | response to drug | hair follicle placode formation | histone deacetylation | neurogenesis | positive regulation of phosphate metabolic process | generation of neurons | response to antibiotic | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | circadian regulation of gene expression | chromatin organization | limb morphogenesis | odontogenesis | neuron development | positive regulation of epithelial to mesenchymal transition | negative regulation of nucleic acid-templated transcription | hemostasis | negative regulation of apoptotic process | regulation of proteolysis | response to growth factor | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | histone deacetylase activity (H3-K14 specific) | negative regulation of peptidyl-lysine acetylation | response to inorganic substance | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of cell differentiation | cellular response to retinoic acid | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | gene silencing | regulation of metabolic process | organic cyclic compound metabolic process | fungiform papilla morphogenesis | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | response to transforming growth factor beta | positive regulation of tumor necrosis factor production | response to stimulus | embryonic limb morphogenesis | maintenance of chromatin silencing | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | NAD-dependent histone deacetylase activity (H3-K14 specific) | response to cocaine | response to stress | positive regulation of JAK-STAT cascade | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | negative regulation of neuron projection development | circadian rhythm | response to alcohol | response to temperature stimulus | rhythmic process | positive regulation of proteolysis | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | cellular response to toxic substance | regulation of DNA binding | positive regulation of gliogenesis | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | protein deacetylase activity | cellular biosynthetic process | embryo development | macromolecule modification | regulation of oligodendrocyte differentiation | histone H3 deacetylation | response to ethanol | tongue development | blood coagulation | regulation of nucleic acid-templated transcription | response to nitrogen compound | negative regulation of MHC class II biosynthetic process | response to nicotine | response to external biotic stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | cellular response to antibiotic | multicellular organism development | NAD-dependent protein deacetylase activity | negative regulation of dendritic spine development | response to purine-containing compound | regulation of collagen biosynthetic process | cellular response to oxidative stress | regulation of phosphorylation | wound healing | cellular response to ammonium ion | ATP-dependent chromatin remodeling | regulation of neuron differentiation | regulation of gene expression | histone deacetylase activity | fungiform papilla development | cellular response to stress | response to lipid | cellular response to heat | negative regulation of gene expression, epigenetic | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | ectodermal placode development | eyelid development in camera-type eye | animal organ morphogenesis | behavioral response to ethanol | response to ammonium ion | regulation of nitrogen compound metabolic process | positive regulation of STAT cascade | negative regulation of DNA-binding transcription factor activity | positive regulation of intracellular signal transduction | negative regulation of DNA binding | regulation of transcription by RNA polymerase II | response to oxidative stress | negative regulation of binding | positive regulation of cell differentiation | epidermal cell differentiation | cardiac muscle hypertrophy | biosynthetic process | protein deacetylation | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | response to hyperoxia | epidermis development | response to toxic substance | skin development | response to xenobiotic stimulus | regulation of tumor necrosis factor production | sensory organ development | NAD-dependent histone deacetylase activity | cellular response to drug | response to bacterium | regulation of interleukin-1 production | regulation of cellular metabolic process | chromatin remodeling | positive regulation of interleukin-1 production | positive regulation of tyrosine phosphorylation of STAT protein | odontogenesis of dentin-containing tooth | response to catecholamine | regulation of collagen metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of protein phosphorylation | histone H4 deacetylation | regulation of RNA metabolic process | response to retinoic acid | coagulation | embryonic morphogenesis | cellular response to transforming growth factor beta stimulus | neuron differentiation | response to monoamine | protein metabolic process | positive regulation of protein modification process | hair cycle | response to organic substance | negative regulation of cell projection organization | regulation of JAK-STAT cascade | response to wounding | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | response to amine | positive regulation of neurogenesis | cell projection organization | metabolic process | positive regulation of cell development | regulation of receptor biosynthetic process | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | positive regulation of glial cell differentiation | cellular response to hydrogen peroxide | hair cycle process | behavior | nucleobase-containing compound metabolic process | cellular response to reactive oxygen species | neuron projection development | response to caffeine | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | response to reactive oxygen species | negative regulation of neuron differentiation | negative regulation of cellular protein metabolic process | gene expression | response to heat | skin epidermis development | regulation of phosphate metabolic process | response to alkaloid | transcription, DNA-templated | positive regulation of cytokine production | camera-type eye development | anatomical structure formation involved in morphogenesis | adult behavior | negative regulation of protein metabolic process | regulation of dendrite development | regulation of glial cell differentiation | regulation of cell communication | regulation of gliogenesis | negative regulation of molecular function | regulation of dendritic spine development | covalent chromatin modification | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | embryonic digit morphogenesis | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | tongue morphogenesis | response to biotic stimulus | dendrite development | regulation of nervous system development | regulation of developmental process | developmental process | organelle organization | cellular protein modification process | positive regulation of oligodendrocyte differentiation | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | fungiform papilla formation | positive regulation of nucleic acid-templated transcription | negative regulation of protein acetylation | response to organonitrogen compound | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | heterocycle metabolic process | cellular response to dopamine | response to anesthetic | positive regulation of metabolic process | chromosome organization | chromatin silencing | response to amphetamine | regulation of cell projection organization | positive regulation of collagen biosynthetic process | cellular metabolic process | positive regulation of receptor biosynthetic process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | negative regulation of cell development | muscle hypertrophy | negative regulation of cell differentiation | regulation of cellular component organization | muscle system process | response to other organism | positive regulation of signaling | cellular response to catecholamine stimulus | hair follicle development | regulation of signaling | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
PcG protein complex | chromosome | intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | nuclear transcriptional repressor complex | ESC/E(Z) complex | cytoplasm | intracellular organelle | histone methyltransferase complex | protein-containing complex | methyltransferase complex | histone deacetylase complex | nucleoplasm | chromatin | nuclear chromosome | transferase complex | Sin3 complex | membrane-bounded organelle | transcriptional repressor complex | nucleus | Sin3-type complex | organelle | SWI/SNF superfamily-type complex | NuRD complex | membrane-enclosed lumen | nuclear chromatin | ATPase complex | intracellular
