QuickView for HDAC6 (gene)
- Gene Symbol:
- HDAC6
Homo sapiens - Full name:
- histone deacetylase 6
- Synonyms:
- CPBHM, HD6, JM21, PPP1R90, histone deacetylase 6, protein phosphatase 1, regulatory subunit 90
- Genomic Location:
- Chr X: 48545431-48568324
- Description:
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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplica...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
Xp11.23
GO Molecular Function
sequence-specific DNA binding | beta-catenin binding | actin binding | transcription regulatory region DNA binding | tubulin deacetylase activity | cation binding | alpha-tubulin binding | histone deacetylase activity (H3-K14 specific) | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | protein-containing complex binding | NAD-dependent histone deacetylase activity (H3-K14 specific) | hydrolase activity | ubiquitin binding | protein deacetylase activity | catalytic activity | beta-tubulin binding | polyubiquitin modification-dependent protein binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | ubiquitin-like protein ligase binding | NAD-dependent protein deacetylase activity | cytoskeletal protein binding | histone deacetylase activity | modification-dependent protein binding | RNA polymerase II regulatory region DNA binding | tau protein binding | dynein complex binding | DNA binding | sequence-specific double-stranded DNA binding | ubiquitin-like protein binding | ion binding | organic cyclic compound binding | NAD-dependent histone deacetylase activity | transcription regulatory region sequence-specific DNA binding | protein binding | misfolded protein binding | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | ubiquitin protein ligase binding | RNA polymerase II regulatory region sequence-specific DNA binding | transition metal ion binding | microtubule binding | Hsp90 protein binding | tubulin binding | deacetylase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | heat shock protein binding | histone deacetylase binding | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | lysosome localization | regulation of supramolecular fiber organization | cell morphogenesis | regulation of hydrogen peroxide-induced cell death | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | dendritic spine development | regulation of microtubule polymerization or depolymerization | regulation of cellular response to oxidative stress | positive regulation of cellular component organization | regulation of response to oxidative stress | neuron projection morphogenesis | proteolysis | regulation of localization | regulation of programmed cell death | negative regulation of protein complex disassembly | peptidyl-amino acid modification | establishment of localization | regulation of autophagy | negative regulation of cellular process | negative regulation of RNA biosynthetic process | histone modification | cell differentiation | response to misfolded protein | tubulin deacetylase activity | nervous system development | response to drug | histone deacetylation | cell part morphogenesis | regulation of microtubule-based movement | neurogenesis | positive regulation of phosphate metabolic process | regulation of protein oligomerization | regulation of organelle organization | positive regulation of cellular component movement | generation of neurons | response to antibiotic | intracellular transport | negative regulation of proteolysis | cellular process | regulation of gene expression, epigenetic | tubulin deacetylation | organic substance catabolic process | regulation of cell motility | localization | cell projection morphogenesis | proteolysis involved in cellular protein catabolic process | chromatin organization | protein transport | developmental growth | positive regulation of peptidyl-serine phosphorylation | neuron development | parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization | dendritic spine organization | negative regulation of microtubule polymerization or depolymerization | negative regulation of nucleic acid-templated transcription | macromolecule localization | regulation of proteolysis | response to growth factor | positive regulation of nitrogen compound metabolic process | histone deacetylase activity (H3-K14 specific) | response to inorganic substance | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of fat cell differentiation | regulation of cell differentiation | response to hydrogen peroxide | regulation of cellular process | regulation of metabolic process | catabolic process | regulation of protein complex assembly | organelle localization | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | response to topologically incorrect protein | cellular aromatic compound metabolic process | cellular component organization | cellular response to topologically incorrect protein | positive regulation of epithelial cell migration | positive regulation of autophagy of mitochondrion | regulation of microtubule depolymerization | response to stimulus | cell morphogenesis involved in neuron differentiation | positive regulation of protein metabolic process | positive regulation of hydrogen peroxide-mediated programmed cell death | NAD-dependent histone deacetylase activity (H3-K14 specific) | response to stress | intracellular protein transport | regulation of intracellular steroid hormone receptor signaling pathway | cellular nitrogen compound biosynthetic process | regulation of response to drug | cellular protein catabolic process | cellular localization | cellular nitrogen compound metabolic process | cellular response to toxic substance | positive regulation of mitophagy in response to mitochondrial depolarization | positive regulation of chaperone-mediated protein complex assembly | regulation of macroautophagy | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | negative regulation of metabolic process | cellular component assembly | protein modification process | protein deacetylase activity | positive regulation of response to oxidative stress | cellular biosynthetic process | macromolecule modification | histone H3 deacetylation | positive regulation of mitochondrion organization | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | organelle assembly | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | regulation of protein stability | cellular response to antibiotic | multicellular organism development | negative regulation of catalytic activity | NAD-dependent protein deacetylase activity | regulation of catalytic activity | cellular response to oxidative stress | regulation of phosphorylation | regulation of protein complex disassembly | regulation of gene expression | histone deacetylase activity | axon development | organic substance transport | cellular response to stress | protein catabolic process | cell projection assembly | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of cellular response to oxidative stress | positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of cell migration | peptide transport | positive regulation of protein complex assembly | regulation of cellular component movement | response to oxidative stress | synapse organization | axonogenesis | mitochondrion localization | positive regulation of cell migration | biosynthetic process | protein deacetylation | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | response to toxic substance | regulation of hydrogen peroxide metabolic process | cell morphogenesis involved in differentiation | negative regulation of microtubule depolymerization | autophagy | NAD-dependent histone deacetylase activity | cellular response to drug | regulation of mitochondrion organization | regulation of cellular response to drug | regulation of cellular metabolic process | misfolded protein transport | positive regulation of response to drug | regulation of protein metabolic process | positive regulation of signal transduction | regulation of androgen receptor signaling pathway | regulation of protein phosphorylation | regulation of locomotion | positive regulation of oxidative stress-induced cell death | regulation of RNA metabolic process | positive regulation of hydrogen peroxide-induced cell death | regulation of protein depolymerization | regulation of microtubule-based process | regulation of autophagy of mitochondrion | protein polyubiquitination | neuron differentiation | regulation of signaling receptor activity | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | protein ubiquitination | Hsp90 deacetylation | regulation of response to reactive oxygen species | cellular macromolecule catabolic process | anatomical structure development | developmental growth involved in morphogenesis | cell projection organization | metabolic process | regulation of receptor biosynthetic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | protein quality control for misfolded or incompletely synthesized proteins | negative regulation of cytoskeleton organization | collateral sprouting | cellular protein localization | negative regulation of hydrogen peroxide metabolic process | amide transport | peptidyl-lysine modification | cellular response to hydrogen peroxide | positive regulation of cell death | nucleobase-containing compound metabolic process | dendritic spine morphogenesis | cellular response to reactive oxygen species | neuron projection development | positive regulation of cellular component biogenesis | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | response to reactive oxygen species | cilium assembly | negative regulation of cellular protein metabolic process | gene expression | positive regulation of programmed cell death | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | positive regulation of autophagy | establishment of protein localization | transcription, DNA-templated | positive regulation of macroautophagy | regulation of peptidyl-serine phosphorylation | ubiquitin-dependent protein catabolic process | dendrite morphogenesis | cilium organization | negative regulation of protein metabolic process | regulation of epithelial cell migration | positive regulation of cellular response to drug | organonitrogen compound catabolic process | regulation of cell communication | aggresome assembly | response to mitochondrial depolarisation | negative regulation of molecular function | covalent chromatin modification | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | cell development | protein localization | protein-containing complex disassembly | positive regulation of phosphorylation | cellular protein metabolic process | anatomical structure morphogenesis | cellular macromolecule localization | cellular macromolecule biosynthetic process | dendrite development | regulation of developmental process | developmental process | organelle organization | positive regulation of mitophagy | peptidyl-lysine deacetylation | cellular protein modification process | regulation of reactive oxygen species metabolic process | positive regulation of protein oligomerization | developmental cell growth | negative regulation of oxidoreductase activity | negative regulation of supramolecular fiber organization | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | cellular response to misfolded protein | cellular metabolic process | positive regulation of receptor biosynthetic process | polyubiquitinated misfolded protein transport | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of cell motility | modification-dependent protein catabolic process | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of cytoskeleton organization | negative regulation of reactive oxygen species metabolic process | positive regulation of signaling | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
supramolecular fiber | dendrite | intracellular membrane-bounded organelle | catalytic complex | late endosome | neuron projection | somatodendritic compartment | microtubule associated complex | dynein complex | cytoplasmic vesicle | cell body | cell | nuclear lumen | multivesicular body | neuronal cell body | microtubule | cytoplasm | cytoplasmic microtubule | intracellular organelle | membrane microdomain | dendritic tree | inclusion body | protein-containing complex | cell projection | endomembrane system | histone deacetylase complex | nucleoplasm | plasma membrane | perikaryon | cell leading edge | membrane raft | vesicle | perinuclear region of cytoplasm | microtubule cytoskeleton | endosome | membrane-bounded organelle | aggresome | nucleus | organelle | cell periphery | axon | membrane-enclosed lumen | plasma membrane raft | cytosol | intracellular vesicle | cytoskeleton | intracellular | caveola | membrane | supramolecular complex
