QuickView for HHIP (gene)

Gene Symbol:

HHIP Homo sapiens

Full name:

hedgehog interacting protein

Synonyms:

HIP, hedgehog-interacting protein

Genomic Location:

Chr 4: 145786623-145879331

Description:

This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface ...

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This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  PAX4_04 ,  CEBPA_01 ,  CREBP1CJUN_01 ,  CREB_Q4_01 ,  AML_Q6 ,  FOXO4_01 ,  CACGTG_MYC_Q2 ,  FOXD3_01 ,  HFH1_01 ,  TTF1_Q6 ,  GGGCATT_MIR365 ,  CTCNANGTGNY_UNKNOWN ,  CREB_Q4 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  ATF_B ,  CREBP1_Q2 ,  ATF_01 ,  CAGGTG_E12_Q6 ,  LHX3_01 ,  CTCAAGA_MIR526B ,  RRAGTTGT_UNKNOWN ,  CREB_02 ,  MYCMAX_01 ,  ATF3_Q6 ,  USF_C ,  NKX25_02 ,  TGCCAAR_NF1_Q6 ,  SOX5_01 ,  RACCACAR_AML_Q6 ,  PTF1BETA_Q6 ,  YCATTAA_UNKNOWN ,  NMYC_01 ,  FREAC2_01 ,  CEBP_Q3 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  ATF1_Q6 ,  PIT1_Q6 ,  GATA4_Q3 ,  CREB_Q2 ,  YTAATTAA_LHX3_01 ,  ZF5_B ,  COREBINDINGFACTOR_Q6 ,  CREB_Q2_01 ,  CREB_01 ,  TAXCREB_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-365

Cytogenetic Map:

4q31.21

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