QuickView for HIF3A;jsessionid=402B4933CA5B757CAE76F7EB9CBFFBCE (gene)
- Gene Symbol:
- HIF3A
Homo sapiens - Full name:
- hypoxia inducible factor 3 alpha subunit
- Synonyms:
- HIF-3A, HIF3-alpha-1, IPAS, MOP7, PASD7, bHLHe17, hypoxia-inducible factor 3-alpha, PAS domain-containing protein 7, basic-helix-loop-helix-PAS protein MOP7, class E basic helix-loop-helix protein 17, inhibitory PAS domain protein, member of PAS protein 7
- Genomic Location:
- Chr 19: 51492145-51538530
- Description:
-
The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors co...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
19q13.32
GO Molecular Function
RNA polymerase II transcription factor activity, sequence-specific DNA binding | nucleic acid binding | DNA binding | organic cyclic compound binding | protein binding | DNA-binding transcription factor activity | protein dimerization activity | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | blood vessel morphogenesis | positive regulation of cellular biosynthetic process | cellular process | response to hypoxia | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | response to stimulus | vasculature development | cellular response to hypoxia | response to stress | cellular nitrogen compound biosynthetic process | tube morphogenesis | programmed cell death | cardiovascular system development | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | protein modification process | cellular biosynthetic process | macromolecule modification | blood vessel development | regulation of nucleic acid-templated transcription | apoptotic process | system development | response to oxygen levels | nitrogen compound metabolic process | multicellular organism development | regulation of gene expression | cellular response to stress | positive regulation of cellular metabolic process | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | angiogenesis | regulation of cellular metabolic process | regulation of RNA metabolic process | protein metabolic process | DNA-binding transcription factor activity | anatomical structure development | metabolic process | regulation of DNA-templated transcription in response to stress | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | gene expression | transcription, DNA-templated | anatomical structure formation involved in morphogenesis | regulation of transcription, DNA-templated | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of transcription from RNA polymerase II promoter in response to hypoxia | developmental process | cellular protein modification process | tube development | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | circulatory system development | positive regulation of gene expression | post-translational protein modification | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear body | nucleoplasm | plasma membrane | nuclear speck | mitochondrion | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | cytosol | intracellular | membrane
