QuickView for HNF1A (gene)

Gene Symbol:

HNF1A Homo sapiens

Full name:

HNF1 homeobox A

Synonyms:

HNF-1A, HNF1, IDDM20, LFB1, MODY3, TCF-1, TCF1, hepatocyte nuclear factor 1-alpha, HNF-1-alpha, albumin proximal factor, hepatic nuclear factor 1, interferon production regulator factor, liver-specific transcription factor LF-B1, transcription factor 1, hepatic

Genomic Location:

Chr 12: 119900932-119924698

Description:

The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance o...

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The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FOXO1_02 ,  RTAAACA_FREAC2_01 ,  CMYB_01 ,  HNF4ALPHA_Q6 ,  MAZR_01 ,  TGANTCA_AP1_C ,  GAGCCTG_MIR484 ,  HNF1_01 ,  TGANNYRGCA_TCF11MAFG_01 ,  HOXA4_Q2 ,  GATA_C ,  YATTNATC_UNKNOWN ,  IPF1_Q4 ,  LYF1_01 ,  GATAAGR_GATA_C ,  HNF1_C ,  SREBP1_Q6 ,  CTTTGA_LEF1_Q2 ,  COUP_01 ,  NRSF_01 ,  GGGAGGRR_MAZ_Q6 ,  HNF4_01 ,  TATAAA_TATA_01 ,  PAX4_02 ,  CAGGTA_AREB6_01 ,  DR1_Q3 ,  HNF4_Q6 ,  CAGNWMCNNNGAC_UNKNOWN ,  CDPCR3_01 ,  AREB6_01 ,  LMO2COM_02 ,  OCT1_03 ,  TGCCAAR_NF1_Q6 ,  YCATTAA_UNKNOWN ,  GFI1_01 ,  HMGIY_Q6 ,  NCX_01 ,  FREAC2_01 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  RTTTNNNYTGGM_UNKNOWN ,  RGTTAMWNATT_HNF1_01 ,  TBP_01 ,  NFKB_Q6_01 ,  SRY_02 ,  AACTTT_UNKNOWN ,  MZF1_02 ,  YNGTTNNNATT_UNKNOWN ,  PPAR_DR1_Q2 ,  CRX_Q4 ,  HNF1_Q6 ,  NFKB_Q6 ,  FREAC4_01 ,  HNF4_01_B ,  GGGTGGRR_PAX4_03

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Cytogenetic Map:

12q24.31

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