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QuickView for HNF1A (gene)


Gene Symbol:
HNF1A Homo sapiens Homo sapiens
Full name:
HNF1 homeobox A
Synonyms:
HNF-1A, HNF1, IDDM20, LFB1, MODY3, TCF-1, TCF1, hepatocyte nuclear factor 1-alpha, HNF-1-alpha, albumin proximal factor, hepatic nuclear factor 1, interferon production regulator factor, liver-specific transcription factor LF-B1, transcription factor 1, hepatic
Genomic Location:
Chr 12: 119900932-119924698
Description:
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance o...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
FOXO1_02 RTAAACA_FREAC2_01 CMYB_01 HNF4ALPHA_Q6 MAZR_01 TGANTCA_AP1_C GAGCCTG_MIR484 HNF1_01 TGANNYRGCA_TCF11MAFG_01 HOXA4_Q2
Cytogenetic Map:
chr 12
12q24.31





GO Molecular Function

transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | DNA binding | organic cyclic compound binding | protein binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | protein dimerization activity | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | pronephros development | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | hormone secretion | establishment of localization | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cell differentiation | glucose homeostasis | positive regulation of cellular biosynthetic process | regulation of transcription initiation from RNA polymerase II promoter | cellular process | secretion | peptide hormone secretion | lymphocyte differentiation | localization | protein transport | immune system development | macromolecule localization | positive regulation of nitrogen compound metabolic process | regulation of pronephros size | regulation of cellular process | leukocyte activation | regulation of metabolic process | regulation of protein complex assembly | hepaticobiliary system development | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | urogenital system development | natural killer cell differentiation | monosaccharide transmembrane transport | cellular nitrogen compound biosynthetic process | secretion by cell | cellular nitrogen compound metabolic process | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | positive regulation of RNA biosynthetic process | hemopoiesis | cellular biosynthetic process | kidney development | cell-cell signaling | insulin secretion | regulation of nucleic acid-templated transcription | leukocyte differentiation | system development | nitrogen compound metabolic process | renal glucose absorption | multicellular organism development | pronephros morphogenesis | kidney morphogenesis | regulation of hormone levels | regulation of gene expression | pancreas development | organic substance transport | positive regulation of cellular metabolic process | animal organ morphogenesis | liver development | regulation of nitrogen compound metabolic process | renal absorption | peptide transport | hexose transmembrane transport | positive regulation of protein complex assembly | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | peptide secretion | cell communication | regulation of cellular metabolic process | homeostatic process | regulation of RNA metabolic process | renal system development | carbohydrate transport | lymphocyte activation | carbohydrate transmembrane transport | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | gland development | anatomical structure development | metabolic process | positive regulation of DNA-templated transcription, initiation | regulation of RNA biosynthetic process | glucose import | amide transport | chemical homeostasis | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | hormone transport | nucleobase-containing compound metabolic process | positive regulation of cellular component biogenesis | organic substance metabolic process | animal organ development | gene expression | regulation of kidney size | renal system process | establishment of protein localization | transcription, DNA-templated | cell activation | glucose transmembrane transport | transmembrane transport | natural killer cell activation | signaling | regulation of transcription, DNA-templated | protein localization | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of DNA-templated transcription, initiation | developmental process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | signal release | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | protein secretion | carbohydrate homeostasis | regulation of cellular component organization | positive regulation of transcription initiation from RNA polymerase II promoter | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | protein-containing complex | membrane-bounded organelle | nucleus | organelle | intracellular