QuickView for HOXB8 (gene)

Gene Symbol:

HOXB8 Homo sapiens

Full name:

homeobox B8

Synonyms:

HOX2, HOX2D, Hox-2.4, homeobox protein Hox-B8, homeo box 2D, homeo box B8, homeobox protein Hox-2.4, homeobox protein Hox-2D

Genomic Location:

Chr 17: 44044707-44047300

Description:

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with ...

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This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FOXO1_02 ,  PR_Q2 ,  RTAAACA_FREAC2_01 ,  CMYB_01 ,  PAX4_04 ,  HNF3ALPHA_Q6 ,  MCAATNNNNNGCG_UNKNOWN ,  PU1_Q6 ,  AGCYRWTTC_UNKNOWN ,  MZF1_01 ,  ZIC1_01 ,  HFH3_01 ,  VDR_Q3 ,  SREBP1_02 ,  TGANNYRGCA_TCF11MAFG_01 ,  HOXA4_Q2 ,  FOXO4_01 ,  OCT_Q6 ,  POU3F2_01 ,  AAAYWAACM_HFH4_01 ,  HFH1_01 ,  TGTGTGA_MIR377 ,  IPF1_Q4 ,  LYF1_01 ,  AMEF2_Q6 ,  FAC1_01 ,  HNF1_C ,  ZIC3_01 ,  PBX1_01 ,  MAF_Q6 ,  OCT1_Q5_01 ,  OCT_C ,  WHN_B ,  ACTGTGA_MIR27A_MIR27B ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  CTTTGTA_MIR524 ,  YAATNRNNNYNATT_UNKNOWN ,  CDP_01 ,  TATAAA_TATA_01 ,  GTGTGAG_MIR342 ,  CEBPDELTA_Q6 ,  OCT1_Q6 ,  RGAANNTTC_HSF1_01 ,  CDP_02 ,  CACCCBINDINGFACTOR_Q6 ,  FOXO3_01 ,  GGATTA_PITX2_Q2 ,  RREB1_01 ,  CAGGTG_E12_Q6 ,  HSF1_01 ,  TST1_01 ,  EGR_Q6 ,  TATA_C ,  SP3_Q3 ,  ZID_01 ,  EVI1_05 ,  ATTCTTT_MIR186 ,  ACTGCCT_MIR34B ,  YKACATTT_UNKNOWN ,  NKX61_01 ,  FOXO1_01 ,  CTTTAAR_UNKNOWN ,  SPZ1_01 ,  GCCNNNWTAAR_UNKNOWN ,  HSF2_01 ,  GATA1_02 ,  PAX8_B ,  OCT1_06 ,  YCATTAA_UNKNOWN ,  GFI1_01 ,  MYB_Q6 ,  HMGIY_Q6 ,  EN1_01 ,  TTGTTT_FOXO4_01 ,  YTAAYNGCT_UNKNOWN ,  AAAYRNCTG_UNKNOWN ,  PIT1_Q6 ,  WTTGKCTG_UNKNOWN ,  HEN1_02 ,  IRF7_01 ,  TEF_Q6 ,  RGAGGAARY_PU1_Q6 ,  ZIC2_01 ,  CTGCAGY_UNKNOWN ,  TGATTTRY_GFI1_01 ,  EGR1_01 ,  AAAGGAT_MIR501 ,  TAANNYSGCG_UNKNOWN ,  MMEF2_Q6 ,  CACBINDINGPROTEIN_Q6 ,  AACTTT_UNKNOWN ,  MZF1_02 ,  PAX4_03 ,  YNGTTNNNATT_UNKNOWN ,  TGACATY_UNKNOWN ,  FOXO4_02 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-208 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-342 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-499

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miRNA binding sites
(Source: miRecords):

hsa-miR-196a Targeted Genes

Cytogenetic Map:

17q21.32

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