QuickView for HPN (gene)

Gene Symbol:

HPN Homo sapiens

Full name:

hepsin

Synonyms:

TMPRSS1, serine protease hepsin, testicular tissue protein Li 85, transmembrane protease serine 1

Genomic Location:

Chr 19: 40223250-40249315

Description:

This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine pro...

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This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SP1_01 ,  RTAAACA_FREAC2_01 ,  HNF1_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  AP2GAMMA_01 ,  COUP_01 ,  NKX22_01 ,  TGACCTY_ERR1_Q2 ,  WTGAAAT_UNKNOWN ,  PAX4_02 ,  CACCCBINDINGFACTOR_Q6 ,  CATGTAA_MIR496 ,  CAGGTG_E12_Q6 ,  PXR_Q2 ,  AP2_Q6_01 ,  GGGCGGR_SP1_Q6 ,  TGCCAAR_NF1_Q6 ,  PAX8_B ,  YCATTAA_UNKNOWN ,  AP2_Q6 ,  PIT1_Q6 ,  RTTTNNNYTGGM_UNKNOWN ,  HNF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-496

Cytogenetic Map:

19q13.11

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