QuickView for HSD17B4 (gene)
- Gene Symbol:
- HSD17B4
Homo sapiens - Full name:
- hydroxysteroid 17-beta dehydrogenase 4
- Synonyms:
- DBP, MFE-2, MPF-2, PRLTS1, SDR8C1, peroxisomal multifunctional enzyme type 2, 17-beta-HSD 4, 17-beta-HSD IV, 17-beta-hydroxysteroid dehydrogenase 4, 17beta-estradiol dehydrogenase type IV, 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase, D-3-hydroxyacyl-CoA dehydratase, D-bifunctional protein, peroxisomal, beta-hydroxyacyl dehydrogenase, beta-keto-reductase, hydroxysteroid dehydrogenase 4, multifunctional protein 2, peroxisomal multifunctional protein 2, short chain dehydrogenase/reductase family 8C member 1
- Genomic Location:
- Chr 5: 118816122-118905923
- Description:
-
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidatio...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
5q23.1
GO Molecular Function
oxidoreductase activity, acting on CH-OH group of donors | steroid dehydrogenase activity | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity | isomerase activity | signaling receptor binding | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | hydro-lyase activity | lyase activity | catalytic activity | long-chain-enoyl-CoA hydratase activity | identical protein binding | protein binding | protein homodimerization activity | protein dimerization activity | 17-beta-hydroxysteroid dehydrogenase (NAD+) activity | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | oxidoreductase activity | 3-hydroxyacyl-CoA dehydrogenase activity
GO Biological Process
purine ribonucleotide metabolic process | peroxisome organization | oxidoreductase activity, acting on CH-OH group of donors | steroid dehydrogenase activity | sulfur compound metabolic process | establishment of localization | fatty acid beta-oxidation | cell differentiation | bile acid biosynthetic process | estrogen metabolic process | intracellular transport | cellular process | organic substance catabolic process | localization | protein transport | nucleotide metabolic process | protein targeting to peroxisome | ribose phosphate metabolic process | macromolecule localization | ribonucleotide metabolic process | establishment of localization in cell | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | steroid biosynthetic process | cellular component organization | cellular lipid metabolic process | purine nucleotide metabolic process | monocarboxylic acid metabolic process | carboxylic acid catabolic process | intracellular protein transport | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | cellular localization | fatty acid catabolic process | androgen metabolic process | cellular nitrogen compound metabolic process | cofactor metabolic process | cellular biosynthetic process | organic hydroxy compound metabolic process | nitrogen compound metabolic process | phosphorus metabolic process | acyl-CoA metabolic process | lipid metabolic process | regulation of hormone levels | organic substance transport | organophosphate metabolic process | small molecule metabolic process | peptide transport | very long-chain fatty-acyl-CoA metabolic process | cellular amide metabolic process | protein localization to organelle | nucleobase-containing small molecule metabolic process | biosynthetic process | lipid biosynthetic process | establishment of protein localization to peroxisome | phosphate-containing compound metabolic process | cellular lipid catabolic process | lipid modification | long-chain fatty acid metabolic process | drug metabolic process | carboxylic acid metabolic process | bile acid metabolic process | establishment of protein localization to organelle | metabolic process | oxidation-reduction process | cellular protein localization | amide transport | nucleobase-containing compound metabolic process | lipid catabolic process | organic substance metabolic process | fatty acid metabolic process | establishment of protein localization | 17-beta-hydroxysteroid dehydrogenase (NAD+) activity | lipid oxidation | steroid metabolic process | protein localization | organic acid metabolic process | hormone metabolic process | cellular macromolecule localization | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | fatty acid beta-oxidation using acyl-CoA oxidase | developmental process | organelle organization | alpha-linolenic acid metabolic process | carbohydrate derivative metabolic process | heterocycle metabolic process | fatty acid oxidation | ossification | protein targeting | osteoblast differentiation | cellular metabolic process | oxidoreductase activity | multicellular organismal process | medium-chain fatty-acyl-CoA metabolic process | 3-hydroxyacyl-CoA dehydrogenase activity
GO Cellular Component
peroxisomal membrane | peroxisomal matrix | intracellular membrane-bounded organelle | organelle membrane | peroxisome | cell | cytoplasm | intracellular organelle | membrane-bounded organelle | organelle | membrane-enclosed lumen | cytosol | intracellular | membrane
