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QuickView for HSPA1B;jsessionid=0B068016959824EF63E8A59CF7B3FAC7 (gene)


Gene Symbol:
HSPA1B Homo sapiens Homo sapiens
Full name:
heat shock protein family A (Hsp70) member 1B
Synonyms:
HSP70-1B, HSP70-2, HSP70.2, heat shock 70 kDa protein 1B, HSP70-1/HSP70-2, HSP70.1/HSP70.2, heat shock 70 kDa protein 1/2, heat shock 70 kDa protein 1A/1B, heat shock 70 kDa protein 2, heat shock 70kD protein 1B, heat shock 70kDa protein 1B
Genomic Location:
Chr 6: 31903503-31906010
Description:
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-protea...
Orthologs:
Mus musculus Rattus norvegicus Saccharomyces cerevisiae Schizosaccharomyces pombe
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 6
6p21.33


Transcripts Names
NM_005346
Protein Names
No proteins found.



GO Molecular Function

enzyme binding | nucleic acid binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | hydrolase activity | carbohydrate derivative binding | unfolded protein binding | ATPase activity | pyrophosphatase activity | catalytic activity | protein domain specific binding | ATP binding | protein N-terminus binding | ubiquitin-like protein ligase binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | ATPase activity, coupled | purine nucleotide binding | ion binding | organic cyclic compound binding | C3HC4-type RING finger domain binding | protein binding involved in protein folding | purine ribonucleoside triphosphate binding | protein binding | misfolded protein binding | ubiquitin protein ligase binding | G-protein coupled receptor binding | hydrolase activity, acting on acid anhydrides | virus receptor activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heat shock protein binding | histone deacetylase binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding | RNA binding

GO Biological Process

positive regulation of immune response | RNA metabolic process | positive regulation of erythrocyte differentiation | regulation of supramolecular fiber organization | purine ribonucleotide metabolic process | regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of cell cycle process | exocytosis | regulation of microtubule polymerization or depolymerization | positive regulation of cellular component organization | neutrophil activation | 'de novo' posttranslational protein folding | protein stabilization | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | establishment of localization | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of protein catabolic process | regulation of organelle organization | cellular process | secretion | positive regulation of microtubule polymerization | organic substance catabolic process | leukocyte degranulation | localization | chaperone-mediated protein folding | nucleotide metabolic process | negative regulation of signaling | regulation of mitotic nuclear division | ribose phosphate metabolic process | regulation of response to cytokine stimulus | negative regulation of apoptotic process | positive regulation of tumor necrosis factor-mediated signaling pathway | regulation of proteolysis | nucleoside triphosphate metabolic process | regulation of cell cycle | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | ribonucleotide metabolic process | regulation of mitotic spindle organization | negative regulation of cellular metabolic process | regulation of cell differentiation | interspecies interaction between organisms | negative regulation of apoptotic signaling pathway | positive regulation of interleukin-8 production | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | catabolic process | regulation of protein complex assembly | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular response to unfolded protein | response to topologically incorrect protein | cellular aromatic compound metabolic process | entry into host cell | viral life cycle | mRNA catabolic process | cellular response to topologically incorrect protein | positive regulation of cellular protein catabolic process | response to stimulus | purine nucleotide metabolic process | neutrophil degranulation | positive regulation of innate immune response | regulation of cellular response to heat | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | response to stress | leukocyte activation involved in immune response | regulation of cell proliferation | regulation of protein ubiquitination | positive regulation of proteolysis involved in cellular protein catabolic process | secretion by cell | response to temperature stimulus | positive regulation of proteolysis | cellular nitrogen compound metabolic process | negative regulation of metabolic process | mRNA metabolic process | nucleobase-containing compound catabolic process | regulation of mitotic spindle assembly | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | positive regulation of response to cytokine stimulus | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of growth | regulation of protein stability | phosphorus metabolic process | leukocyte mediated immunity | cellular response to oxidative stress | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | viral entry into host cell | regulation of microtubule nucleation | cellular response to stress | RNA catabolic process | organophosphate metabolic process | cellular response to heat | positive regulation of microtubule nucleation | regulation of spindle assembly | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | positive regulation of intracellular signal transduction | positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway | positive regulation of protein complex assembly | vesicle-mediated transport | response to oxidative stress | positive regulation of cell differentiation | nucleobase-containing small molecule metabolic process | positive regulation of myeloid cell differentiation | negative regulation of extrinsic apoptotic signaling pathway | 'de novo' protein folding | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | regulated exocytosis | cellular heat acclimation | regulation of apoptotic signaling pathway | phosphate-containing compound metabolic process | regulation of cellular metabolic process | heat acclimation | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of tumor necrosis factor-mediated signaling pathway | cell activation involved in immune response | positive regulation of cytoskeleton organization | myeloid cell activation involved in immune response | regulation of protein metabolic process | protein binding involved in protein folding | positive regulation of signal transduction | aromatic compound catabolic process | neutrophil activation involved in immune response | regulation of cytokine-mediated signaling pathway | regulation of RNA metabolic process | negative regulation of protein ubiquitination | viral process | negative regulation of cell growth | regulation of nucleotide-binding oligomerization domain containing signaling pathway | regulation of mitotic cell cycle | regulation of microtubule-based process | drug metabolic process | positive regulation of molecular function | regulation of proteasomal ubiquitin-dependent protein catabolic process | regulation of growth | response to organic substance | regulation of innate immune response | regulation of hemopoiesis | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | cellular macromolecule catabolic process | metabolic process | regulation of microtubule polymerization | positive regulation of supramolecular fiber organization | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | regulation of erythrocyte differentiation | immune response | nucleobase-containing compound metabolic process | positive regulation of cellular component biogenesis | organic substance metabolic process | protein folding | virus receptor activity | negative regulation of gene expression | negative regulation of cellular protein metabolic process | positive regulation of NF-kappaB transcription factor activity | response to heat | negative regulation of inclusion body assembly | positive regulation of cytokine production | cell activation | negative regulation of protein metabolic process | positive regulation of cytokine-mediated signaling pathway | regulation of cell communication | negative regulation of signal transduction | regulation of transcription, DNA-templated | response to unfolded protein | regulation of cytokine production | chaperone cofactor-dependent protein refolding | regulation of developmental process | regulation of cell growth | regulation of inclusion body assembly | carbohydrate derivative metabolic process | negative regulation of cell proliferation | positive regulation of protein polymerization | neutrophil mediated immunity | heterocycle metabolic process | protein refolding | positive regulation of metabolic process | immune system process | cellular metabolic process | ATP metabolic process | cellular response to organic substance | regulation of cell death | regulation of organelle assembly | negative regulation of cell death | regulation of ubiquitin-dependent protein catabolic process | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of cytoskeleton organization | positive regulation of signaling | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process

GO Cellular Component

secretory granule | centriole | intracellular membrane-bounded organelle | catalytic complex | adherens junction | microtubule organizing center | focal adhesion | cytoplasmic vesicle | COP9 signalosome | cell | nuclear lumen | cytoplasm | cell-substrate junction | intracellular organelle | endoplasmic reticulum | ubiquitin ligase complex | nuclear body | ficolin-1-rich granule lumen | inclusion body | centrosome | protein-containing complex | secretory vesicle | endomembrane system | nucleoplasm | nuclear speck | ribonucleoprotein complex | vesicle | transferase complex | perinuclear region of cytoplasm | extracellular exosome | microtubule cytoskeleton | mitochondrion | extracellular region | membrane-bounded organelle | extracellular vesicle | aggresome | nucleus | organelle | extracellular space | membrane-enclosed lumen | cell-substrate adherens junction | blood microparticle | cytosol | intracellular vesicle | cytoskeleton | intracellular | cell junction