QuickView for HSPA8;jsessionid=C262038B4892D5430F359962914CFDC2 (gene)

Gene Symbol:

HSPA8 Homo sapiens

Full name:

heat shock protein family A (Hsp70) member 8

Synonyms:

HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71, heat shock cognate 71 kDa protein, LPS-associated protein 1, N-myristoyltransferase inhibitor protein 71, constitutive heat shock protein 70, epididymis luminal protein 33, epididymis secretory sperm binding protein Li 72p, heat shock 70kDa protein 8, heat shock 70kd protein 10, heat shock cognate protein 54, lipopolysaccharide-associated protein 1

Genomic Location:

Chr 11: 122433410-122438054

Description:

This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions ...

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This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTCNRGNNNNTTC_HSF_Q6 ,  ACTTTAT_MIR1425P ,  GCCATNTTG_YY1_Q6 ,  GGGAGGRR_MAZ_Q6 ,  RGAANNTTC_HSF1_01 ,  HSF1_01 ,  TTCYRGAA_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  MGGAAGTG_GABP_B ,  HSF2_01 ,  YY1_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-33

Cytogenetic Map:

11q24.1

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