QuickView for HSPH1;jsessionid=7691D4633560F05858B58D10A83DDD36 (gene)
- Gene Symbol:
- HSPH1
Homo sapiens - Full name:
- heat shock protein family H (Hsp110) member 1
- Synonyms:
- HSP105, HSP105A, HSP105B, NY-CO-25, heat shock protein 105 kDa, antigen NY-CO-25, heat shock 105kDa/110kDa protein 1
- Genomic Location:
- Chr 13: 30608762-30634117
- Description:
-
This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the c...
- Orthologs:
- Mus musculus , Rattus norvegicus , Saccharomyces cerevisiae , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
13q12.3
GO Molecular Function
alpha-tubulin binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | molecular function regulator | ATP binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | purine ribonucleotide binding | tubulin binding | enzyme regulator activity | adenyl ribonucleotide binding | drug binding | adenyl-nucleotide exchange factor activity | ATPase regulator activity | heterocyclic compound binding | small molecule binding
GO Biological Process
negative regulation of phosphorylation | regulation of hydrogen peroxide-induced cell death | positive regulation of macromolecule biosynthetic process | negative regulation of MAPK cascade | regulation of cellular response to oxidative stress | regulation of response to oxidative stress | 'de novo' posttranslational protein folding | regulation of cellular localization | regulation of localization | regulation of programmed cell death | negative regulation of cellular response to oxidative stress | positive regulation of peptidyl-tyrosine phosphorylation | establishment of localization | regulation of immune system process | negative regulation of cellular process | positive regulation of lymphocyte activation | negative regulation of protein phosphorylation | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | negative regulation of stress-activated protein kinase signaling cascade | positive regulation of cellular biosynthetic process | cellular process | localization | chaperone-mediated protein folding | regulation of MHC class I biosynthetic process | negative regulation of signaling | positive regulation of protein kinase activity | negative regulation of apoptotic process | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | negative regulation of apoptotic signaling pathway | negative regulation of hydrogen peroxide-mediated programmed cell death | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | negative regulation of p38MAPK cascade | positive regulation of cellular protein metabolic process | negative regulation of oxidative stress-induced cell death | response to topologically incorrect protein | negative regulation of response to drug | response to stimulus | regulation of cellular protein localization | regulation of cellular response to heat | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | response to stress | regulation of response to drug | positive regulation of cell-cell adhesion | positive regulation of cell activation | positive regulation of T cell activation | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of cell adhesion | molecular function regulator | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | regulation of protein tyrosine kinase activity | regulation of signal transduction | negative regulation of phosphate metabolic process | regulation of MAPK cascade | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | regulation of catalytic activity | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | negative regulation of cellular protein localization | regulation of T cell activation | regulation of gene expression | negative regulation of hydrogen peroxide-induced cell death | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | vesicle-mediated transport | regulation of transcription by RNA polymerase II | 'de novo' protein folding | positive regulation of NK T cell activation | regulation of cellular protein metabolic process | negative regulation of stress-activated MAPK cascade | regulation of apoptotic signaling pathway | regulation of cellular response to drug | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of molecular function | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | import into cell | regulation of response to reactive oxygen species | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | negative regulation of response to oxidative stress | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of programmed cell death | endocytosis | negative regulation of intrinsic apoptotic signaling pathway | protein folding | negative regulation of cellular protein metabolic process | regulation of cell activation | positive regulation of kinase activity | regulation of phosphate metabolic process | negative regulation of protein metabolic process | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of signal transduction | regulation of transcription, DNA-templated | positive regulation of phosphorylation | positive regulation of protein tyrosine kinase activity | enzyme regulator activity | response to unfolded protein | chaperone cofactor-dependent protein refolding | receptor-mediated endocytosis | positive regulation of alpha-beta T cell activation | adenyl-nucleotide exchange factor activity | positive regulation of transcription, DNA-templated | regulation of cell-cell adhesion | ATPase regulator activity | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | positive regulation of metabolic process | regulation of protein localization | regulation of cell death | positive regulation of MHC class I biosynthetic process | negative regulation of cell death | positive regulation of leukocyte cell-cell adhesion | regulation of signaling | regulation of p38MAPK cascade | positive regulation of gene expression | negative regulation of establishment of protein localization to mitochondrion | regulation of phosphorus metabolic process
GO Cellular Component
supramolecular fiber | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | nuclear lumen | cytoplasmic vesicle lumen | microtubule | cytoplasm | endocytic vesicle lumen | intracellular organelle | protein-containing complex | nucleoplasm | vesicle | extracellular exosome | microtubule cytoskeleton | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | membrane-enclosed lumen | cytosol | intracellular vesicle | cytoskeleton | endocytic vesicle | intracellular | supramolecular complex | vesicle lumen
