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QuickView for HTR1B (gene)


Gene Symbol:
HTR1B Homo sapiens Homo sapiens
Full name:
5-hydroxytryptamine receptor 1B
Synonyms:
5-HT-1B, 5-HT-1D-beta, 5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled, serotonin 1D beta receptor, serotonin receptor 1B
Genomic Location:
Chr 6: 78228667-78229839
Description:
The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric diso...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Bos taurus Canis lupus familiaris Gallus gallus Pan troglodytes Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 6
6q14.1


Transcripts Names
NM_000863
Protein Names
A8K215
Q4VAY7
P28222
X5D7I5



GO Molecular Function

neurotransmitter receptor activity | cation binding | neurotransmitter binding | transmembrane signaling receptor activity | G-protein coupled receptor activity | G-protein coupled amine receptor activity | serotonin binding | signaling receptor activity | ion binding | organic cyclic compound binding | amine binding | protein binding | G-protein coupled serotonin receptor activity | drug binding | heterocyclic compound binding

GO Biological Process

positive regulation of smooth muscle cell proliferation | negative regulation of G-protein coupled receptor protein signaling pathway | regulation of blood vessel diameter | regulation of localization | establishment of localization | response to hormone | negative regulation of cellular process | negative regulation of serotonin secretion | response to drug | bone remodeling | response to antibiotic | positive regulation of vascular smooth muscle cell proliferation | cellular process | regulation of catecholamine secretion | localization | tissue remodeling | negative regulation of signaling | chemical synaptic transmission | cellular response to temperature stimulus | negative regulation of secretion | regulation of behavior | negative regulation of neurotransmitter transport | drinking behavior | regulation of cellular process | G-protein coupled receptor internalization | cellular response to organonitrogen compound | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | G-protein coupled receptor activity | response to stimulus | regulation of blood vessel size | response to cocaine | regulation of response to drug | regulation of cell proliferation | G-protein coupled amine receptor activity | response to alcohol | response to temperature stimulus | negative regulation of transport | blood circulation | G-protein coupled receptor signaling pathway | modulation of chemical synaptic transmission | cell-cell signaling | response to ethanol | negative regulation of blood vessel diameter | response to nitrogen compound | regulation of signal transduction | negative regulation of secretion by cell | regulation of synaptic transmission, GABAergic | regulation of synaptic transmission, glutamatergic | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | response to lipid | synaptic signaling | response to ammonium ion | response to corticosteroid | vesicle-mediated transport | cellular response to alkaloid | vasoconstriction | negative regulation of ion transport | response to toxic substance | regulation of serotonin secretion | response to xenobiotic stimulus | negative regulation of synaptic transmission, glutamatergic | cellular response to drug | cell communication | receptor internalization | positive regulation of cell proliferation | protein kinase C-activating G-protein coupled receptor signaling pathway | negative regulation of synaptic transmission, GABAergic | regulation of tube size | regulation of dopamine secretion | negative adaptation of signaling pathway | response to organic substance | import into cell | metabolic process | response to mineralocorticoid | regulation of tube diameter | endocytosis | regulation of secretion | behavior | organic substance metabolic process | desensitization of G-protein coupled receptor protein signaling pathway | G-protein coupled serotonin receptor activity | response to alkaloid | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | negative regulation of signal transduction | signaling | feeding behavior | response to organic cyclic compound | G-protein coupled serotonin receptor signaling pathway | regulation of ion transport | receptor-mediated endocytosis | regulation of G-protein coupled receptor protein signaling pathway | regulation of transport | receptor metabolic process | serotonin receptor signaling pathway | response to organonitrogen compound | adenylate cyclase-inhibiting serotonin receptor signaling pathway | negative regulation of synaptic transmission | response to anesthetic | cellular metabolic process | cellular response to organic substance | regulation of smooth muscle cell proliferation | response to steroid hormone | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

integral component of membrane | dendrite | neuron projection | somatodendritic compartment | cell | intrinsic component of membrane | cytoplasm | dendritic tree | cell projection | plasma membrane | integral component of plasma membrane | cell periphery | intracellular | membrane | intrinsic component of plasma membrane