QuickView for HYAL3;jsessionid=176BDEE376F12E03E598CF656B88C902 (gene)

Gene Symbol:

HYAL3 Homo sapiens

Full name:

hyaluronoglucosaminidase 3

Synonyms:

HYAL-3, LUCA-3, LUCA3, hyaluronidase-3, lung carcinoma protein 3

Genomic Location:

Chr 3: 50305266-50311903

Description:

This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded ...

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This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GATA_C ,  GATAAGR_GATA_C ,  GGGCGGR_SP1_Q6 ,  LMO2COM_02 ,  ARGGGTTAA_UNKNOWN ,  RGAGGAARY_PU1_Q6

Cytogenetic Map:

3p21.31

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