QuickView for HYR domain (biogroup)

Description:: The HYR (HYalin Repeat) domain is an extracellular domain of about 80-100amino acids. It has been named after the hyalin protein, which is composedexclusively of repeats of this domain. The HYR domain is found in severaleukaryotic proteins, either in multiple copies as in hyalin or in associationwith other domains like the CCP (sushi) domain, the Von Willebrand factor typeA (VWA) domain, the EGF-like domain, the calcium-binding EGF-like domain, the pentraxin domain, the CUB domain, the LDL-receptor class A domain, the C-type lectin domain or the discoidin domain. As the HYR domains of hyalin have been shown to contain the ligand for the hyalin cell surface receptor, the HYR domain can also be expected to play a direct role in cellular adhesion in other proteins in which it is present.Secondary structure predictions of the HYR domain indicate an all-beta foldincluding seven beta-strands. The HYR domain shares clear sequencesimilarities limited to the C-terminal region with the Fn3 and PKD domains andis believed to belong to the immunoglobulin-like fold.

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