QuickView for Hippo (gene)

Gene Symbol:

STK3 Homo sapiens

Full name:

serine/threonine kinase 3

Synonyms:

KRS1, MST2, serine/threonine-protein kinase 3, KB-1458E12.1, MST-2, STE20-like kinase MST2, mammalian STE20-like protein kinase 2, serine/threonine kinase 3 (STE20 homolog, yeast), serine/threonine kinase 3 (Ste20, yeast homolog), serine/threonine-protein kinase Krs-1

Genomic Location:

Chr 8: 99536037-99907085

Description:

This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which pro...

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This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  TGIF_01 ,  TAL1ALPHAE47_01 ,  GGGACCA_MIR133A_MIR133B ,  CAGCACT_MIR5123P ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  TAL1BETAE47_01 ,  CAGGTG_E12_Q6 ,  E47_02 ,  GR_Q6 ,  MYOD_Q6 ,  ACCAAAG_MIR9 ,  HSF_Q6 ,  MEIS1_01 ,  FREAC2_01 ,  TAATTA_CHX10_01 ,  TAL1BETAITF2_01 ,  TGACAGNY_MEIS1_01 ,  TAANNYSGCG_UNKNOWN ,  AACTTT_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-9

Cytogenetic Map:

8q22.2

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