QuickView for Holliday junction resolvase (gene)

Gene Symbol:

GEN1 Homo sapiens

Full name:

GEN1, Holliday junction 5' flap endonuclease

Synonyms:

Gen, flap endonuclease GEN homolog 1, Gen endonuclease homolog 1, Holliday junction resolvase

Genomic Location:

Chr 2: 17798658-17826911

Description:

This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, w...

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This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PR_Q2 ,  PBX1_02 ,  GABP_B ,  TGANTCA_AP1_C ,  HNF1_01 ,  AP3_Q6 ,  E2F1_Q4_01 ,  E2F4DP1_01 ,  NFKAPPAB_01 ,  AMEF2_Q6 ,  HNF1_C ,  GR_Q6_01 ,  PBX1_01 ,  GGGAGGRR_MAZ_Q6 ,  STAT_Q6 ,  TATAAA_TATA_01 ,  CEBP_Q2 ,  CEBPB_01 ,  E2F_Q6 ,  E2F1_Q6_01 ,  TATA_C ,  E2F_Q4 ,  E2F1DP2_01 ,  S8_01 ,  MGGAAGTG_GABP_B ,  CTTTAAR_UNKNOWN ,  STAT3_01 ,  HMEF2_Q6 ,  E2F1DP1_01 ,  STAT_01 ,  E2F_Q4_01 ,  HMGIY_Q6 ,  ELK1_01 ,  TAATTA_CHX10_01 ,  E2F1DP1RB_01 ,  SCGGAAGY_ELK1_02 ,  E2F_02 ,  TTCYNRGAA_STAT5B_01 ,  E2F1_Q3 ,  E2F4DP2_01 ,  STAT1_01 ,  RCGCANGCGY_NRF1_Q6 ,  NFKB_Q6_01 ,  MMEF2_Q6 ,  ZF5_B ,  FOXM1_01 ,  E2F_Q3 ,  E2F_Q3_01 ,  HNF1_Q6 ,  HNF6_Q6 ,  E2F1_Q6 ,  SGCGSSAAA_E2F1DP2_01

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Cytogenetic Map:

2p24.2

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