QuickView for Hoxb5 (gene)

Gene Symbol:

HOXB5 Homo sapiens

Full name:

homeobox B5

Synonyms:

HHO.C10, HOX2, HOX2A, HU-1, Hox2.1, homeobox protein Hox-B5, homeo box 2A, homeo box B5, homeobox protein HHO.C10, homeobox protein Hox-2A, homeobox protein Hu-1

Genomic Location:

Chr 17: 44023618-44026102

Description:

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is ass...

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This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SMTTTTGT_UNKNOWN ,  GATA1_01 ,  ARNT_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  AML_Q6 ,  HEN1_01 ,  TTTTGAG_MIR373 ,  MYCMAX_03 ,  YTATTTTNR_MEF2_02 ,  CACGTG_MYC_Q2 ,  SRF_Q6 ,  MAX_01 ,  TTTGTAG_MIR520D ,  IPF1_Q4 ,  XBP1_01 ,  CAGTGTT_MIR141_MIR200A ,  AMEF2_Q6 ,  ARNT_02 ,  TAGCTTT_MIR9 ,  GR_Q6_01 ,  TTF1_Q6 ,  TGACCTY_ERR1_Q2 ,  CREB_Q3 ,  OSF2_Q6 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  MYCMAX_02 ,  RGAANNTTC_HSF1_01 ,  TAATGTG_MIR323 ,  SREBP1_01 ,  CACCCBINDINGFACTOR_Q6 ,  CAGGTG_E12_Q6 ,  AP4_Q6 ,  GAGCTGG_MIR337 ,  GTCTTCC_MIR7 ,  EVI1_05 ,  MYCMAX_01 ,  CATRRAGC_UNKNOWN ,  SRF_Q4 ,  ATGTTTC_MIR494 ,  OCT1_03 ,  TAATAAT_MIR126 ,  POU1F1_Q6 ,  NF1_Q6_01 ,  SOX5_01 ,  USF_01 ,  PAX8_B ,  RACCACAR_AML_Q6 ,  HMEF2_Q6 ,  YCATTAA_UNKNOWN ,  TCTCTCC_MIR185 ,  MYB_Q6 ,  AATGTGA_MIR23A_MIR23B ,  TTGTTT_FOXO4_01 ,  CART1_01 ,  PIT1_Q6 ,  IK2_01 ,  HEN1_02 ,  CCCNNNNNNAAGWT_UNKNOWN ,  SRF_Q5_01 ,  TGATTTRY_GFI1_01 ,  CTTTGT_LEF1_Q2 ,  TBP_01 ,  CAGCTG_AP4_Q5 ,  SRY_02 ,  AP4_Q5 ,  USF_02 ,  PAX2_02 ,  ACCATTT_MIR522 ,  SRF_C ,  HOX13_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-7

Cytogenetic Map:

17q21.32

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