QuickView for IARS (gene)
- Gene Symbol:
- IARS
Homo sapiens - Full name:
- isoleucyl-tRNA synthetase
- Synonyms:
- GRIDHH, IARS1, ILERS, ILRS, IRS, PRO0785, isoleucine--tRNA ligase, cytoplasmic, isoleucine tRNA ligase 1, cytoplasmic
- Genomic Location:
- Chr 9: 94012446-94095859
- Description:
-
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tR...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
9q22.31
GO Molecular Function
GTPase binding | enzyme binding | nucleic acid binding | ribonucleotide binding | tRNA binding | carboxylic ester hydrolase activity | nucleotide binding | hydrolase activity | carbohydrate derivative binding | catalytic activity | aminoacyl-tRNA ligase activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | hydrolase activity, acting on ester bonds | aminoacyl-tRNA editing activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | ligase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heterocyclic compound binding | isoleucine-tRNA ligase activity | small molecule binding | RNA binding
GO Biological Process
RNA metabolic process | tRNA aminoacylation | cell differentiation | cellular process | aminoacyl-tRNA metabolism involved in translational fidelity | cellular amino acid metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | peptide biosynthetic process | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | cellular biosynthetic process | nitrogen compound metabolic process | small molecule metabolic process | cellular amide metabolic process | tRNA aminoacylation for protein translation | isoleucyl-tRNA aminoacylation | translation | biosynthetic process | aminoacyl-tRNA editing activity | peptide metabolic process | carboxylic acid metabolic process | tRNA metabolic process | protein metabolic process | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | amide biosynthetic process | organic acid metabolic process | cellular protein metabolic process | cellular macromolecule biosynthetic process | developmental process | regulation of translational fidelity | ncRNA metabolic process | heterocycle metabolic process | ossification | osteoblast differentiation | cellular metabolic process | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
cell | cytoplasm | protein-containing complex | aminoacyl-tRNA synthetase multienzyme complex | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cytosol | intracellular | membrane
