QuickView for IFN-Beta (gene)

Gene Symbol:

IFNB1 Homo sapiens

Full name:

interferon beta 1

Synonyms:

IFB, IFF, IFN-beta, IFNB, interferon beta, fibroblast interferon, interferon, beta 1, fibroblast, interferon-beta

Genomic Location:

Chr 9: 21067104-21067943

Description:

This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell d...

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This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

IRF1_01 ,  NFAT_Q6 ,  NFKAPPAB_01 ,  CTAWWWATA_RSRFC4_Q2 ,  NFKAPPAB65_01 ,  TATAAA_TATA_01 ,  IRF_Q6 ,  IRF7_01 ,  IK1_01 ,  CREL_01 ,  ICSBP_Q6 ,  TBP_01 ,  NFKB_Q6_01 ,  ISRE_01 ,  AACTTT_UNKNOWN ,  GGARNTKYCCA_UNKNOWN ,  NFKB_Q6 ,  NFKB_C ,  STTTCRNTTT_IRF_Q6 ,  IRF2_01 ,  TCF11MAFG_01

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Cytogenetic Map:

9p21.3

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