QuickView for IGF-1 (gene)
- Gene Symbol:
- Igf1
Mus musculus - Full name:
- insulin-like growth factor 1
- Synonyms:
- C730016P09Rik, Igf-1, Igf-I, insulin-like growth factor I, somatomedin
- Genomic Location:
- Chr 10: 87322146-87394546
- Description:
-
This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. This gene is predominantly expressed in the liver and the encoded protein undergoes proteolytic processing to generate a disulfide-linked mature polypeptide. Transgenic disruption of this gene in...
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Danio rerio , Bos taurus , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
AAAYRNCTG_UNKNOWN , MYOD_01 , AP4_01 , AACTTT_UNKNOWN , HOX13_01 , COMP1_01 , HEN1_02 , GATA3_01 , EVI1_05 , GATA1_04
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-1 , Predicted Gene Targets for miR-142-5p , Predicted Gene Targets for miR-150 , Predicted Gene Targets for miR-18 , Predicted Gene Targets for miR-186 , Predicted Gene Targets for miR-19 , Predicted Gene Targets for miR-26 , Predicted Gene Targets for miR-27 , Predicted Gene Targets for miR-30-3p , Predicted Gene Targets for miR-320
GO Molecular Function
protein kinase activator activity | protein serine/threonine kinase activator activity | enzyme activator activity | protein kinase regulator activity | kinase regulator activity | protein-containing complex binding | lipid binding | signaling receptor binding | hormone activity | molecular function regulator | integrin binding | organic cyclic compound binding | cell adhesion molecule binding | protein binding | insulin receptor binding | receptor regulator activity | kinase activator activity | growth factor activity | receptor ligand activity | insulin-like growth factor receptor binding | enzyme regulator activity | steroid binding
GO Biological Process
positive regulation of smooth muscle cell proliferation | negative regulation of smooth muscle cell apoptotic process | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | positive regulation of glycogen biosynthetic process | positive regulation of striated muscle cell differentiation | positive regulation of hormone biosynthetic process | regulation of muscle system process | regulation of cell cycle process | protein kinase activator activity | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of cysteine-type endopeptidase activity | regulation of intracellular protein transport | protein serine/threonine kinase activator activity | negative regulation of MAPK cascade | negative regulation of immune system process | positive regulation of Ras protein signal transduction | detection of stimulus | cellular response to glucose stimulus | positive regulation of cellular component organization | regulation of neurogenesis | developmental process involved in reproduction | regulation of cellular localization | positive regulation of ATP metabolic process | intracellular signal transduction | enzyme activator activity | regulation of cell development | protein stabilization | regulation of localization | prostate gland growth | protein kinase regulator activity | morphogenesis of an epithelium | positive regulation of steroid hormone biosynthetic process | positive regulation of striated muscle tissue development | positive regulation of embryonic development | regulation of carbohydrate metabolic process | regulation of programmed cell death | regulation of oogenesis | regulation of cardiac muscle cell differentiation | positive regulation of peptidyl-tyrosine phosphorylation | negative regulation of cysteine-type endopeptidase activity | regulation of immune system process | response to hormone | regulation of nitric oxide biosynthetic process | negative regulation of neuron death | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | positive regulation of lymphocyte activation | bone development | regulation of heart growth | regulation of protein import | cell differentiation | positive regulation of epithelial cell proliferation | positive regulation of fibroblast proliferation | bone mineralization | respiratory tube development | detection of mechanical stimulus involved in sensory perception | type I pneumocyte differentiation | striated muscle cell development | nervous system development | negative regulation of mitochondrion organization | negative regulation of oligodendrocyte apoptotic process | response to drug | multicellular organism growth | organ growth | negative regulation of protein phosphorylation | cellular chemical homeostasis | neurogenesis | glucose homeostasis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of endothelial cell proliferation | positive regulation of cellular component movement | generation of neurons | positive regulation of protein secretion | response to antibiotic | sensory perception of mechanical stimulus | negative regulation of proteolysis | positive regulation of vascular smooth muscle cell proliferation | regulation of neuron death | regulation of oocyte development | positive regulation of cellular biosynthetic process | cellular process | positive regulation of glycoprotein biosynthetic process | regulation of glucose import | regulation of cell motility | cellular homeostasis | regulation of steroid hormone biosynthetic process | regulation of glycolytic process | epithelial tube morphogenesis | extrinsic apoptotic signaling pathway | regulation of calcium-mediated signaling | tissue remodeling | negative regulation of signaling | developmental growth | regulation of cell growth involved in cardiac muscle cell development | myotube cell development | kinase regulator activity | reproductive system development | regulation of mitotic nuclear division | regulation of embryonic development | regulation of striated muscle tissue development | positive regulation of protein kinase activity | negative regulation of apoptotic process | regulation of proteolysis | regulation of cell cycle | positive regulation of catalytic activity | regulation of tyrosine phosphorylation of STAT protein | lung epithelium development | negative regulation of release of cytochrome c from mitochondria | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of binding | regulation of fat cell differentiation | regulation of cell differentiation | positive regulation of cardiac muscle hypertrophy | positive regulation of muscle cell differentiation | muscle structure development | muscle cell differentiation | negative regulation of apoptotic signaling pathway | regeneration | glycoprotein biosynthetic process | regulation of protein kinase B signaling | regulation of cellular process | positive regulation of cell growth | regulation of osteoblast differentiation | regulation of apoptotic process | regulation of metabolic process | gliogenesis | positive regulation of activated T cell proliferation | positive regulation of cellular protein metabolic process | epithelium development | cellular response to organonitrogen compound | insulin-like growth factor receptor signaling pathway | prostate gland epithelium morphogenesis | MAPK cascade | urogenital system development | positive regulation of epithelial cell migration | regulation of peptide secretion | response to stimulus | negative regulation of epithelial cell apoptotic process | positive regulation of vascular endothelial cell proliferation | vasculature development | muscle cell development | lung lobe morphogenesis | regulation of glycoprotein biosynthetic process | regulation of cellular protein localization | chondroitin sulfate proteoglycan biosynthetic process | respiratory system development | regulation of peptidyl-tyrosine phosphorylation | blood vessel remodeling | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | positive regulation of phosphatidylinositol 3-kinase signaling | gland morphogenesis | response to stress | regulation of intracellular steroid hormone receptor signaling pathway | positive regulation of JAK-STAT cascade | positive regulation of cellular protein localization | positive regulation of lymphocyte proliferation | posttranscriptional regulation of gene expression | regulation of cell proliferation | negative regulation of oocyte development | positive regulation of lipid biosynthetic process | tube morphogenesis | response to peptide | positive regulation of cell-cell adhesion | positive regulation of glucose import | circadian rhythm | response to glucose | proteoglycan metabolic process | regulation of smooth muscle cell migration | programmed cell death | phosphatidylinositol-mediated signaling | regulation of transcription regulatory region DNA binding | positive regulation of cell activation | reproduction | response to alcohol | cardiovascular system development | response to temperature stimulus | rhythmic process | positive regulation of T cell activation | regulation of DNA binding | positive regulation of blood vessel endothelial cell migration | positive regulation of gliogenesis | hormone activity | carbohydrate derivative biosynthetic process | regulation of protein transport | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | protein modification process | regulation of peptide transport | regulation of cell adhesion | regulation of steroid biosynthetic process | cellular biosynthetic process | macromolecule modification | negative regulation of ERK1 and ERK2 cascade | regulation of steroid metabolic process | activation of protein kinase activity | regulation of intracellular transport | molecular function regulator | regulation of establishment or maintenance of cell polarity | response to ethanol | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | water homeostasis | detection of abiotic stimulus | regulation of neurotransmitter levels | response to nitrogen compound | lung alveolus development | apoptotic process | protein kinase B signaling | cellular response to hormone stimulus | positive regulation of mononuclear cell proliferation | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | regulation of protein stability | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | cellular glucose homeostasis | cellular response to peptide hormone stimulus | regulation of peptidase activity | regulation of MAPK cascade | phosphorus metabolic process | learning or memory | type II pneumocyte differentiation | mammary gland development | positive regulation of smooth muscle cell migration | positive regulation of muscle organ development | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of hormone levels | regulation of ossification | negative regulation of peptidase activity | wound healing | regulation of T cell activation | positive regulation of cell cycle | regulation of activated T cell proliferation | positive regulation of mitotic cell cycle | regulation of small GTPase mediated signal transduction | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | pancreas development | positive regulation of secretion | nervous system process | cellular response to peptide | branching involved in prostate gland morphogenesis | positive regulation of intracellular protein transport | exocrine pancreas development | regulation of protein import into nucleus, translocation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | animal organ morphogenesis | regulation of protein localization to nucleus | positive regulation of ATP biosynthetic process | lung secretory cell differentiation | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of STAT cascade | positive regulation of intracellular signal transduction | regulation of cellular component movement | regulation of transcription by RNA polymerase II | regulation of smooth muscle cell apoptotic process | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of cell differentiation | regulation of endothelial cell migration | activation of protein kinase B activity | positive regulation of calcium-mediated signaling | negative regulation of extrinsic apoptotic signaling pathway | cognition | positive regulation of steroid metabolic process | positive regulation of cell migration | negative regulation of intracellular steroid hormone receptor signaling pathway | positive regulation of glucose transmembrane transport | positive regulation of glycolytic process | cell proliferation | positive regulation of protein localization to nucleus | biosynthetic process | regulation of hormone metabolic process | regulation of cellular protein metabolic process | positive regulation of trophectodermal cell proliferation | positive regulation of T cell proliferation | glial cell differentiation | positive regulation of ossification | phosphorylation | inositol lipid-mediated signaling | response to toxic substance | regulation of apoptotic signaling pathway | positive regulation of cell growth involved in cardiac muscle cell development | regulation of epithelial cell apoptotic process | protein phosphorylation | phosphate-containing compound metabolic process | sensory organ development | regulation of mitochondrion organization | regulation of muscle cell apoptotic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of tyrosine phosphorylation of STAT protein | regulation of glial cell proliferation | cellular response to amyloid-beta | regulation of protein metabolic process | positive regulation of signal transduction | inner ear development | regulation of androgen receptor signaling pathway | homeostatic process | positive regulation of cell proliferation | response to monosaccharide | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | lung vasculature development | regulation of RNA metabolic process | positive regulation of transport | chondroitin sulfate proteoglycan metabolic process | regulation of lipid biosynthetic process | striated muscle cell differentiation | negative regulation of cholangiocyte apoptotic process | ossification involved in bone maturation | apoptotic signaling pathway | regulation of mitotic cell cycle | positive regulation of glial cell proliferation | positive regulation of molecular function | regulation of nucleocytoplasmic transport | positive regulation of osteoblast differentiation | lung epithelial cell differentiation | prostate gland stromal morphogenesis | activation of MAPK activity | regulation of signaling receptor activity | receptor regulator activity | positive regulation of organ growth | protein metabolic process | regulation of fibroblast proliferation | regulation of cardiac muscle hypertrophy | regulation of establishment of protein localization | cellular response to insulin-like growth factor stimulus | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | regulation of cardiac muscle tissue development | tissue morphogenesis | regulation of protein import into nucleus | digestive system development | regulation of insulin-like growth factor receptor signaling pathway | branching morphogenesis of an epithelial tube | regulation of JAK-STAT cascade | regulation of kinase activity | response to wounding | response to mechanical stimulus | detection of stimulus involved in sensory perception | positive regulation of steroid biosynthetic process | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | phosphatidylinositol 3-kinase signaling | positive regulation of myoblast proliferation | anatomical structure development | kinase activator activity | cell surface receptor signaling pathway | positive regulation of neurogenesis | positive regulation of small GTPase mediated signal transduction | regulation of glucose metabolic process | growth factor activity | regulation of neural precursor cell proliferation | metabolic process | positive regulation of cell development | positive regulation of glucose metabolic process | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | developmental maturation | negative regulation of programmed cell death | regulation of myoblast proliferation | ear development | cellular response to carbohydrate stimulus | negative regulation of muscle cell apoptotic process | negative regulation of vascular associated smooth muscle cell apoptotic process | chemical homeostasis | regulation of secretion | behavior | receptor ligand activity | organic substance metabolic process | connective tissue development | maintenance of cell number | cell death | negative regulation of gene expression | regulation of glucose transmembrane transport | animal organ development | regulation of endothelial cell proliferation | negative regulation of cellular protein metabolic process | regulation of cell activation | regulation of protein secretion | positive regulation of kinase activity | regulation of calcineurin-NFAT signaling cascade | response to heat | regulation of striated muscle cell differentiation | regulation of ATP metabolic process | regulation of phosphate metabolic process | biomineral tissue development | prostate gland morphogenesis | positive regulation of binding | detection of mechanical stimulus | positive regulation of muscle tissue development | positive regulation of glycoprotein metabolic process | positive regulation of calcineurin-NFAT signaling cascade | positive regulation of intracellular transport | positive regulation of endothelial cell migration | negative regulation of glial cell apoptotic process | cell activation | positive regulation of MAPK cascade | lung development | morphogenesis of a branching epithelium | positive regulation of protein transport | regulation of reactive oxygen species biosynthetic process | memory | negative regulation of protein metabolic process | sensory perception | regulation of epithelial cell migration | positive regulation of carbohydrate metabolic process | skeletal muscle tissue regeneration | positive regulation of cardiac muscle cell differentiation | bone maturation | negative regulation of androgen receptor signaling pathway | prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis | positive regulation of protein import into nucleus, translocation | regulation of cell communication | regulation of blood vessel endothelial cell migration | regulation of gliogenesis | negative regulation of molecular function | negative regulation of signal transduction | positive regulation of developmental growth | signaling | positive regulation of growth | response to amyloid-beta | regulation of transcription, DNA-templated | myotube differentiation | myoblast differentiation | cell development | positive regulation of DNA binding | negative regulation of peptidyl-tyrosine phosphorylation | regulation of developmental growth | regulation of T cell proliferation | sensory perception of chemical stimulus | regulation of epithelial cell proliferation | extrinsic apoptotic signaling pathway in absence of ligand | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | regulation of Ras protein signal transduction | morphogenesis of a branching structure | anatomical structure morphogenesis | prostate gland development | regulation of endopeptidase activity | cellular macromolecule biosynthetic process | positive regulation of fat cell differentiation | positive regulation of MAP kinase activity | positive regulation of protein import into nucleus | regulation of organ growth | regulation of cerebellar granule cell precursor proliferation | reproductive structure development | regulation of nervous system development | regulation of developmental process | regulation of ion transport | positive regulation of neural precursor cell proliferation | developmental process | regulation of muscle cell differentiation | positive regulation of protein import | lung cell differentiation | positive regulation of cell cycle process | regulation of cell growth | regulation of calcium ion transport | cellular protein modification process | tube development | carbohydrate derivative metabolic process | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | positive regulation of heart growth | response to organonitrogen compound | lung morphogenesis | regulation of glycogen biosynthetic process | epithelial cell differentiation | ERK1 and ERK2 cascade | positive regulation of transcription by RNA polymerase II | negative regulation of hydrolase activity | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of generation of precursor metabolites and energy | regulation of lipid metabolic process | positive regulation of metabolic process | ossification | osteoblast differentiation | positive regulation of lipid metabolic process | myoblast proliferation | positive regulation of cerebellar granule cell precursor proliferation | skeletal system development | lung lobe development | cellular metabolic process | cellular response to organic substance | regulation of protein localization | exocrine system development | regulation of cell death | positive regulation of cardiac muscle tissue development | sensory perception of smell | regulation of smooth muscle cell proliferation | positive regulation of cell motility | response to carbohydrate | regulation of translation | negative regulation of cell death | bone mineralization involved in bone maturation | negative regulation of cell development | circulatory system development | positive regulation of insulin-like growth factor receptor signaling pathway | carbohydrate homeostasis | glycoprotein metabolic process | muscle hypertrophy | positive regulation of nucleocytoplasmic transport | tissue regeneration | positive regulation of leukocyte cell-cell adhesion | skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration | negative regulation of cell differentiation | regulation of cellular component organization | muscle system process | positive regulation of signaling | positive regulation of mitotic nuclear division | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | negative regulation of endopeptidase activity | positive regulation of gene expression | regulation of glycogen metabolic process | proteoglycan biosynthetic process | regulation of hormone biosynthetic process | positive regulation of transcription regulatory region DNA binding | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | exocytic vesicle | extracellular matrix | insulin-like growth factor binding protein complex | somatodendritic compartment | cytoplasmic vesicle | cell body | cell | neuronal cell body | plasma membrane protein complex | cytoplasm | collagen-containing extracellular matrix | intracellular organelle | insulin-like growth factor ternary complex | platelet alpha granule | protein-containing complex | secretory vesicle | endomembrane system | plasma membrane | vesicle | transport vesicle | alphav-beta3 integrin-IGF-1-IGF1R complex | interstitial matrix | extracellular region | membrane-bounded organelle | organelle | extracellular space | cell periphery | intracellular vesicle | intracellular | membrane
