QuickView for IGF-binding protein 3 (gene)

Gene Symbol:

IGFBP3 Homo sapiens

Full name:

insulin like growth factor binding protein 3

Synonyms:

BP-53, IBP3, insulin-like growth factor-binding protein 3, IBP-3, IGF-binding protein 3, IGFBP-3, acid stable subunit of the 140 K IGF complex, binding protein 29, binding protein 53, growth hormone-dependent binding protein

Genomic Location:

Chr 7: 45918369-45927396

Description:

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the ...

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This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  TTTGCAC_MIR19A_MIR19B ,  NFAT_Q6 ,  GCANCTGNY_MYOD_Q6 ,  GGGYGTGNY_UNKNOWN ,  GTGGTGA_MIR197 ,  T3R_Q6 ,  CAGCTG_AP4_Q5

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-381

miRNA binding sites
(Source: miRecords):

hsa-miR-125b Targeted Genes

Cytogenetic Map:

7p12.3

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