QuickView for IKLF (gene)

Gene Symbol:

KLF5 Homo sapiens

Full name:

Kruppel like factor 5

Synonyms:

BTEB2, CKLF, IKLF, Krueppel-like factor 5, (intestinal Kruppel-like factor, BTE-binding protein 2, GC box binding protein 2, Klf5C isoform, Kruppel-like factor 5 (intestinal), basic transcription element binding protein 2, colon krueppel-like factor, colon kruppel-like factor, intestinal-enriched krueppel-like factor, intestinal-enriched kruppel-like factor, transcription factor BTEB2

Genomic Location:

Chr 13: 72531143-72549677

Description:

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. I...

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This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  NKX25_01 ,  TGGAAA_NFAT_Q4_01 ,  CMYB_01 ,  TGANTCA_AP1_C ,  TTANTCA_UNKNOWN ,  HOXA4_Q2 ,  GATA3_01 ,  E2F1_Q4_01 ,  PPARA_01 ,  TTTTGAG_MIR373 ,  TTGCWCAAY_CEBPB_02 ,  YTATTTTNR_MEF2_02 ,  CTATGCA_MIR153 ,  EVI1_04 ,  CEBP_Q2_01 ,  AACTGGA_MIR145 ,  E2F_Q6_01 ,  AREB6_04 ,  WGTTNNNNNAAA_UNKNOWN ,  TTF1_Q6 ,  MYB_Q5_01 ,  EGR2_01 ,  CEBPB_01 ,  GGGYGTGNY_UNKNOWN ,  CAGGTA_AREB6_01 ,  GGATTA_PITX2_Q2 ,  RP58_01 ,  E2F1_Q6_01 ,  CAGCTTT_MIR320 ,  GR_Q6 ,  TST1_01 ,  RRAGTTGT_UNKNOWN ,  GTTTGTT_MIR495 ,  ACCAAAG_MIR9 ,  GGGCGGR_SP1_Q6 ,  AP1_Q2_01 ,  CTTTAAR_UNKNOWN ,  GCM_Q2 ,  MEIS1_01 ,  TGTTTGY_HNF3_Q6 ,  E2F_03 ,  E2F_Q4_01 ,  RNGTGGGC_UNKNOWN ,  MYB_Q6 ,  HMGIY_Q6 ,  AATGTGA_MIR23A_MIR23B ,  HAND1E47_01 ,  TTGTTT_FOXO4_01 ,  GR_01 ,  ATATGCA_MIR448 ,  CEBP_C ,  AAAYRNCTG_UNKNOWN ,  RTTTNNNYTGGM_UNKNOWN ,  GATA1_05 ,  E2F1_Q3 ,  TGACAGNY_MEIS1_01 ,  WCAANNNYCAG_UNKNOWN ,  CAGCTG_AP4_Q5 ,  SP1_Q6_01 ,  E2F_Q3 ,  E2F_Q3_01 ,  EGR3_01 ,  FOXO4_02 ,  GGGTGGRR_PAX4_03 ,  E2F1_Q6 ,  MYB_Q3

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-505

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Cytogenetic Map:

13q22.1

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