QuickView for IL-1A (gene)

Gene Symbol:

IL1A Homo sapiens

Full name:

interleukin 1 alpha

Synonyms:

IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin-1 alpha, IL-1 alpha, hematopoietin-1, preinterleukin 1 alpha, pro-interleukin-1-alpha

Genomic Location:

Chr 2: 113247963-113259442

Description:

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury...

View Full Description

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PR_Q2 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  NFKAPPAB_01 ,  ATGTACA_MIR493 ,  CTTTGTA_MIR524 ,  RYTGCNWTGGNR_UNKNOWN ,  CTCAAGA_MIR526B ,  NFKB_C

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-543

Cytogenetic Map:

2q14.1

search → result