QuickView for IL-1RA (gene)
- Gene Symbol:
- IL1RN
Homo sapiens - Full name:
- interleukin 1 receptor antagonist
- Synonyms:
- DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4, interleukin-1 receptor antagonist protein, IL1 inhibitor, intracellular IL-1 receptor antagonist type II, intracellular interleukin-1 receptor antagonist (icIL-1ra), type II interleukin-1 receptor antagonist
- Genomic Location:
- Chr 2: 113591941-113608064
- Description:
-
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spannin...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- miRNA binding sites
(Source: miRecords):
- Cytogenetic Map:
-
2q14.1
GO Molecular Function
cytokine binding | receptor antagonist activity | interleukin-1, type II receptor binding | interleukin-1 type II receptor antagonist activity | receptor inhibitor activity | signaling receptor binding | cytokine receptor binding | interleukin-1 receptor antagonist activity | growth factor binding | molecular function regulator | interleukin-1 binding | protein binding | receptor regulator activity | interleukin-1 receptor binding | receptor ligand activity | interleukin-1 type I receptor antagonist activity | cytokine activity | growth factor receptor binding | interleukin-1, type I receptor binding
GO Biological Process
regulation of JUN kinase activity | negative regulation of signaling receptor activity | response to extracellular stimulus | response to nutrient levels | response to cytokine | response to interleukin-1 | cell motility | response to lipopolysaccharide | regulation of localization | regulation of programmed cell death | hormone secretion | establishment of localization | response to hormone | negative regulation of cellular process | regulation of MAP kinase activity | defense response | response to drug | receptor antagonist activity | positive regulation of phosphate metabolic process | cellular process | secretion | peptide hormone secretion | regulation of cell motility | localization | protein transport | negative regulation of glutamate secretion | negative regulation of signaling | cellular response to norepinephrine stimulus | regulation of embryonic development | female pregnancy | positive regulation of protein kinase activity | negative regulation of amino acid transport | macromolecule localization | regulation of response to cytokine stimulus | negative regulation of apoptotic process | negative regulation of secretion | interleukin-1 type II receptor antagonist activity | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | granulocyte chemotaxis | negative regulation of cell motility | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | cellular response to molecule of bacterial origin | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | receptor inhibitor activity | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | neutrophil chemotaxis | positive regulation of protein metabolic process | negative regulation of cell adhesion | response to stress | regulation of heterotypic cell-cell adhesion | multicellular organismal homeostasis | response to starvation | inflammatory response to antigenic stimulus | reproduction | secretion by cell | response to molecule of bacterial origin | negative regulation of transport | interleukin-1 receptor antagonist activity | cellular response to organic cyclic compound | positive regulation of protein serine/threonine kinase activity | regulation of cell adhesion | cell-cell signaling | cell chemotaxis | insulin secretion | molecular function regulator | negative regulation of interleukin-1-mediated signaling pathway | leukocyte migration | regulation of membrane potential | regulation of cellular response to stress | locomotion | response to nitrogen compound | response to external biotic stimulus | reproductive process | regulation of signal transduction | negative regulation of secretion by cell | response to activity | cell migration | regulation of MAPK cascade | learning or memory | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of phosphorylation | regulation of hormone levels | organic substance transport | response to lipid | nervous system process | extracellular negative regulation of signal transduction | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of JNK cascade | interleukin-1-mediated signaling pathway | small molecule metabolic process | peptide transport | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | response to corticosteroid | regulation of cellular component movement | negative regulation of heterotypic cell-cell adhesion | acute-phase response | cognition | cellular response to cytokine stimulus | sensory perception of pain | regulation of cellular protein metabolic process | negative regulation of ion transport | regulation of glutamate secretion | negative regulation of membrane potential | response to bacterium | negative regulation of cell-cell adhesion | peptide secretion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | response to catecholamine | inflammatory response | regulation of protein metabolic process | positive regulation of signal transduction | leukocyte chemotaxis | homeostatic process | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | regulation of locomotion | fever generation | carboxylic acid metabolic process | positive regulation of molecular function | regulation of signaling receptor activity | response to monoamine | receptor regulator activity | chronic inflammatory response | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | regulation of interleukin-1-mediated signaling pathway | regulation of intracellular signal transduction | cell surface receptor signaling pathway | negative regulation of response to cytokine stimulus | metabolic process | negative regulation of programmed cell death | regulation of cell-cell adhesion involved in gastrulation | amide transport | regulation of secretion | behavior | receptor ligand activity | positive regulation of interleukin-6 production | immune response | hormone transport | interleukin-1 type I receptor antagonist activity | cytokine activity | organic substance metabolic process | negative regulation of cellular component movement | positive regulation of kinase activity | regulation of phosphate metabolic process | establishment of protein localization | positive regulation of cytokine production | regulation of JNK cascade | positive regulation of MAPK cascade | temperature homeostasis | memory | sensory perception | response to norepinephrine | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | response to organic cyclic compound | protein localization | organic acid metabolic process | positive regulation of phosphorylation | regulation of cytokine production | positive regulation of MAP kinase activity | response to biotic stimulus | regulation of developmental process | regulation of ion transport | cellular response to interleukin-1 | chronic inflammatory response to antigenic stimulus | regulation of gastrulation | regulation of transport | regulation of cell-cell adhesion | heat generation | signal release | response to organonitrogen compound | negative regulation of cytokine-mediated signaling pathway | regulation of anion transport | positive regulation of JUN kinase activity | positive regulation of metabolic process | acute inflammatory response | immune system process | cellular metabolic process | cellular response to organic substance | regulation of cell death | protein secretion | response to steroid hormone | negative regulation of cell death | regulation of interleukin-6 production | neutrophil migration | chemotaxis | negative regulation of locomotion | regulation of I-kappaB kinase/NF-kappaB signaling | response to other organism | positive regulation of signaling | cellular response to catecholamine stimulus | signal transduction | regulation of signaling | response to glucocorticoid | cellular response to lipopolysaccharide | multicellular organismal process | response to interleukin-4 | regulation of phosphorus metabolic process
GO Cellular Component
cell | cytoplasm | plasma membrane | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | intracellular | membrane
