QuickView for IL-5 (gene)

Gene Symbol:

IL5 Homo sapiens

Full name:

interleukin 5

Synonyms:

EDF, IL-5, TRF, interleukin-5, B-cell differentiation factor I, T-cell replacing factor, colony-stimulating factor, eosinophil, eosinophil differentiation factor

Genomic Location:

Chr 5: 131905035-131907113

Description:

This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory disease...

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This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TTANTCA_UNKNOWN ,  GATA3_01 ,  GATA1_04 ,  NKX62_Q2 ,  HNF3B_01 ,  POU1F1_Q6

Cytogenetic Map:

5q31.1

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