QuickView for IL21 (gene)

Gene Symbol:

IL21 Homo sapiens

Full name:

interleukin 21

Synonyms:

CVID11, IL-21, Za11, interleukin-21, interleukin-21 isoform

Genomic Location:

Chr 4: 123739272-123761662

Description:

This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dy...

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This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  RTAAACA_FREAC2_01 ,  FXR_Q3 ,  STAT4_01 ,  TGANTCA_AP1_C ,  GATA1_01 ,  TTANTCA_UNKNOWN ,  POU3F2_01 ,  YATTNATC_UNKNOWN ,  ARP1_01 ,  RYTGCNWTGGNR_UNKNOWN ,  TITF1_Q3 ,  FOXO3_01 ,  TST1_01 ,  EGR_Q6 ,  HNF3B_01 ,  OCT1_03 ,  POU1F1_Q6 ,  TGATTTRY_GFI1_01 ,  ICSBP_Q6 ,  CTTTGT_LEF1_Q2 ,  CDC5_01 ,  AACTTT_UNKNOWN

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Cytogenetic Map:

4q27

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