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QuickView for IL31RA;jsessionid=450922DCC1408E0CAF9877BC3C29A605 (gene)


Gene Symbol:
IL31RA Homo sapiens Homo sapiens
Full name:
interleukin 31 receptor A
Synonyms:
CRL, CRL3, GLM-R, GLMR, GPL, IL-31RA, PLCA2, PRO21384, hGLM-R, interleukin-31 receptor subunit alpha, IL-31 receptor subunit alpha, IL-31R subunit alpha, class I cytokine receptor, cytokine receptor-like 3, gp130-like monocyte receptor, soluble type I cytokine receptor CRL3, zcytoR17
Genomic Location:
Chr 5: 55183091-55248738
Description:
The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced...
Orthologs:
Mus musculus Rattus norvegicus Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 5
5q11.2





GO Molecular Function

cytokine binding | kinase binding | protein kinase binding | transmembrane signaling receptor activity | enzyme binding | signaling receptor activity | cytokine receptor activity | transcription coactivator activity | protein binding | transcription coregulator activity

GO Biological Process

negative regulation of leukocyte activation | adaptive immune response | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | response to cytokine | intracellular signal transduction | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | defense response to other organism | regulation of immune system process | myeloid cell differentiation | negative regulation of cellular process | cell differentiation | JAK-STAT cascade | defense response | positive regulation of phosphate metabolic process | positive regulation of cellular biosynthetic process | cellular process | immune system development | glandular epithelial cell differentiation | negative regulation of apoptotic process | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | tissue development | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | type 2 immune response | positive regulation of cellular protein metabolic process | epithelium development | MAPK cascade | T cell cytokine production | response to stimulus | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | positive regulation of JAK-STAT cascade | regulation of cell proliferation | inflammatory response to antigenic stimulus | macrophage differentiation | positive regulation of RNA biosynthetic process | hemopoiesis | protein modification process | macromolecule modification | regulation of nucleic acid-templated transcription | leukocyte differentiation | negative regulation of macrophage activation | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | phosphorus metabolic process | leukocyte mediated immunity | regulation of phosphorylation | monocyte differentiation | regulation of gene expression | myeloid leukocyte differentiation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | CD4-positive, alpha-beta T cell cytokine production | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | positive regulation of STAT cascade | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | phosphorylation | cytokine production involved in immune response | protein phosphorylation | phosphate-containing compound metabolic process | regulation of macrophage activation | cytokine receptor activity | cell communication | regulation of cellular metabolic process | positive regulation of tyrosine phosphorylation of STAT protein | negative regulation of cell activation | inflammatory response | T cell mediated immunity | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | T-helper 2 cell cytokine production | transcription coactivator activity | regulation of RNA metabolic process | acute inflammatory response to antigenic stimulus | cytokine production | protein metabolic process | positive regulation of protein modification process | response to organic substance | regulation of JAK-STAT cascade | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | immune response | organic substance metabolic process | animal organ development | regulation of cell activation | regulation of phosphate metabolic process | regulation of cell communication | signaling | regulation of transcription, DNA-templated | positive regulation of phosphorylation | cellular protein metabolic process | response to biotic stimulus | developmental process | cellular protein modification process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | epithelial cell differentiation | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | acute inflammatory response | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of cell death | negative regulation of cell death | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

presynaptic membrane | integral component of membrane | synapse | neuron projection | cell | intrinsic component of membrane | synaptic membrane | external side of plasma membrane | receptor complex | presynapse | protein-containing complex | cell projection | plasma membrane | cell periphery | axon | cell surface | intracellular | cell junction | membrane