QuickView for IL4 (gene)

Gene Symbol:

IL4 Homo sapiens

Full name:

interleukin 4

Synonyms:

BCGF-1, BCGF1, BSF-1, BSF1, IL-4, interleukin-4, B cell growth factor 1, B_cell stimulatory factor 1, binetrakin, interleukin 4 variant 2, lymphocyte stimulatory factor 1, pitrakinra

Genomic Location:

Chr 5: 132037272-132046267

Description:

The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play...

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The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  CMYB_01 ,  NFAT_Q6 ,  GATAAGR_GATA_C ,  CTAWWWATA_RSRFC4_Q2 ,  EVI1_03 ,  CAGGTG_E12_Q6 ,  EVI1_02 ,  EVI1_05 ,  CCAWYNNGAAR_UNKNOWN ,  TGCTGAY_UNKNOWN ,  HSF_Q6 ,  TGTTTGY_HNF3_Q6 ,  AREB6_03 ,  HLF_01 ,  GATA4_Q3 ,  GATA1_05 ,  IRF7_01 ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  ISRE_01 ,  GCTNWTTGK_UNKNOWN ,  PPAR_DR1_Q2 ,  STTTCRNTTT_IRF_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-410

Cytogenetic Map:

5q31.1

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