QuickView for IL6ST;jsessionid=D61C2B4F1394EB18C9E9AB1F0B93EA30 (gene)

Gene Symbol:

IL6ST Homo sapiens

Full name:

interleukin 6 signal transducer

Synonyms:

CD130, CDW130, GP130, IL-6RB, interleukin-6 receptor subunit beta, CD130 antigen, IL-6 receptor subunit beta, IL-6R subunit beta, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, gp130, oncostatin M receptor, interleukin receptor beta chain, membrane glycoprotein 130, membrane glycoprotein gp130, oncostatin-M receptor subunit alpha

Genomic Location:

Chr 5: 55272451-55326520

Description:

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to...

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The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  FOXO1_02 ,  RTAAACA_FREAC2_01 ,  AAGCCAT_MIR135A_MIR135B ,  FOXO4_01 ,  E4BP4_01 ,  AACTGAC_MIR223 ,  GGGACCA_MIR133A_MIR133B ,  TTAYRTAA_E4BP4_01 ,  NFKAPPAB65_01 ,  WTGAAAT_UNKNOWN ,  GGTGTGT_MIR329 ,  RGAANNTTC_HSF1_01 ,  CCAWYNNGAAR_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  STAT_01 ,  FREAC2_01 ,  TTGTTT_FOXO4_01 ,  WGGAATGY_TEF1_Q6 ,  AAGCACT_MIR520F ,  TCCATTKW_UNKNOWN ,  NFKB_Q6_01 ,  GCTNWTTGK_UNKNOWN ,  CCAATNNSNNNGCG_UNKNOWN ,  AACTTT_UNKNOWN ,  FOXO4_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-223

Cytogenetic Map:

5q11.2

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