QuickView for ILK (gene)

Gene Symbol:

ILK Homo sapiens

Full name:

integrin linked kinase

Synonyms:

HEL-S-28, ILK-1, ILK-2, P59, p59ILK, integrin-linked protein kinase, 59 kDa serine/threonine-protein kinase, epididymis secretory protein Li 28, integrin-linked kinase-2

Genomic Location:

Chr 11: 6581540-6588677

Description:

This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of th...

View Full Description

This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYC_Q2 ,  CACGTG_MYC_Q2 ,  ZF5_01 ,  NFKAPPAB65_01 ,  GGGAGGRR_MAZ_Q6 ,  EGR_Q6 ,  NFKB_Q6_01 ,  USF2_Q6 ,  NFKB_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-31

Cytogenetic Map:

11p15.4

search → result