QuickView for IMPDH1 (gene)

Gene Symbol:

IMPDH1 Homo sapiens

Full name:

inosine monophosphate dehydrogenase 1

Synonyms:

IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608, inosine-5'-monophosphate dehydrogenase 1, IMP (inosine 5'-monophosphate) dehydrogenase 1, IMP (inosine monophosphate) dehydrogenase 1, IMPD 1, IMPDH 1

Genomic Location:

Chr 7: 127819567-127837272

Description:

The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa t...

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The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYOD_Q6_01 ,  TTTGCAC_MIR19A_MIR19B ,  HEN1_01 ,  E4BP4_01 ,  AAAYWAACM_HFH4_01 ,  CTTTGCA_MIR527 ,  ZIC3_01 ,  E2A_Q2 ,  TTAYRTAA_E4BP4_01 ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  CEBPB_01 ,  GGATTA_PITX2_Q2 ,  FREAC3_01 ,  RREB1_01 ,  ETS2_B ,  HNF4_Q6 ,  FOXJ2_01 ,  GGGCGGR_SP1_Q6 ,  CREBP1_01 ,  AP1_Q2_01 ,  PTF1BETA_Q6 ,  HEN1_02 ,  RGAGGAARY_PU1_Q6 ,  ZIC2_01 ,  EGR1_01 ,  CAGCTG_AP4_Q5 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  ETS1_B ,  CEBPGAMMA_Q6 ,  LMO2COM_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-29

Cytogenetic Map:

7q32.1

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