QuickView for INSR (gene)

Gene Symbol:

INSR Homo sapiens

Full name:

insulin receptor

Synonyms:

CD220, HHF5, insulin receptor, IR

Genomic Location:

Chr 19: 7063266-7245011

Description:

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as ...

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This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  GNCF_01 ,  TGACCTY_ERR1_Q2 ,  ACTGTGA_MIR27A_MIR27B ,  HNF4_DR1_Q3 ,  HNF4_01 ,  DR1_Q3 ,  HNF4_Q6 ,  GGGCGGR_SP1_Q6 ,  TTGTTT_FOXO4_01 ,  COUP_DR1_Q6 ,  CAGCTG_AP4_Q5 ,  AP4_Q5 ,  PPAR_DR1_Q2 ,  TGACCTTG_SF1_Q6 ,  HNF4_01_B ,  FOXO4_02 ,  SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-27

Cytogenetic Map:

19p13.2

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