Bookmark
Forward
Export Results
QuickView for ISWI family (biogroup)
- Description:
- This entry represent the ISWI family. Its members include ISWI from fruit flies and SMCA1/SMCA5 (SNF2L/SNF2H) from mammals. ISWI is part of the NURF complex, which is an ATP-dependent chromatin remodeling complex that regulates transcription by catalysing nucleosome sliding. Its structure has been solved. SMCA5 is a homologue of Drosophila ISWI, which is a major catalytic ATPase subunit of several ISWI-type chromatin remodeling complexes. Its SLIDE domain can associate with UV-damaged chromatin to specifically promote CSB protein recruitment and to resolve damage-stalled transcription. It can be recruited to DNA double-strand breaks in a poly(ADP-ribose) polymerase 1 (PARP1)-dependent manner.
SELECTED ORGANISM:
