QuickView for ITGA3;jsessionid=200935E61C7B6A34BAAB0486BE7015E2 (gene)

Gene Symbol:

ITGA3 Homo sapiens

Full name:

integrin subunit alpha 3

Synonyms:

CD49C, FRP-2, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a, integrin alpha-3, CD49 antigen-like family member C, alpha 3 subunit of VLA-3 receptor, antigen CD49C, antigen identified by monoclonal antibody J143, galactoprotein B3, integrin alpha 3, integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor), testicular tissue protein Li 96, testicular tissue protein Li 98, very late activation protein 3 receptor, alpha-3 subunit

Genomic Location:

Chr 17: 45488730-45522843

Description:

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. Th...

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The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PAX4_04 ,  HNF3ALPHA_Q6 ,  TFIIA_Q6 ,  MYOD_01 ,  MZF1_01 ,  AREB6_02 ,  FOX_Q2 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  HFH3_01 ,  ZF5_01 ,  AAAYWAACM_HFH4_01 ,  GTGACTT_MIR224 ,  FAC1_01 ,  COUP_01 ,  CTTTGTA_MIR524 ,  GGGAGGRR_MAZ_Q6 ,  TFIII_Q6 ,  GGGYGTGNY_UNKNOWN ,  FOXO3_01 ,  GGATTA_PITX2_Q2 ,  CAGGTG_E12_Q6 ,  HNF3_Q6 ,  HNF4_Q6 ,  GGGCGGR_SP1_Q6 ,  TGCTGAY_UNKNOWN ,  E2F1_Q3_01 ,  CTTTAAR_UNKNOWN ,  E47_01 ,  HFH4_01 ,  GCCNNNWTAAR_UNKNOWN ,  TGTTTGY_HNF3_Q6 ,  NCX_01 ,  GTGCCTT_MIR506 ,  TTGTTT_FOXO4_01 ,  WGGAATGY_TEF1_Q6 ,  CHOP_01 ,  CTGYNNCTYTAA_UNKNOWN ,  CAGCTG_AP4_Q5 ,  ERR1_Q2 ,  CCTNTMAGA_UNKNOWN ,  SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-124a

Cytogenetic Map:

17q21.33

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