QuickView for ITPR2;jsessionid=FB35326D0A36B05690ACA1FF9EEA1498 (gene)

Gene Symbol:

ITPR2 Homo sapiens

Full name:

inositol 1,4,5-trisphosphate receptor type 2

Synonyms:

ANHD, CFAP48, INSP3R2, IP3R2, inositol 1,4,5-trisphosphate receptor type 2, IP3 receptor, IP3R 2, cilia and flagella associated protein 48, type 2 InsP3 receptor

Genomic Location:

Chr 12: 26379552-26877398

Description:

The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is invol...

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The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  MYOD_Q6_01 ,  ETS_Q4 ,  RYTTCCTG_ETS2_B ,  PEA3_Q6 ,  CATTTCA_MIR203 ,  CAGGTG_E12_Q6 ,  ETS2_B ,  GGGCGGR_SP1_Q6 ,  GTGCCAA_MIR96 ,  MGGAAGTG_GABP_B ,  RGAGGAARY_PU1_Q6 ,  ETS1_B ,  ELF1_Q6 ,  OLF1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-505

Cytogenetic Map:

12p11.23

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