QuickView for JNK3 (gene)

Gene Symbol:

MAPK10 Homo sapiens

Full name:

mitogen-activated protein kinase 10

Synonyms:

JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK, mitogen-activated protein kinase 10, JNK3 alpha protein kinase, MAP kinase 10, MAP kinase p49 3F12, c-Jun N-terminal kinase 3, stress activated protein kinase beta, stress-activated protein kinase 1b, stress-activated protein kinase JNK3

Genomic Location:

Chr 4: 87156656-87593307

Description:

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons i...

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The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  FOXO1_02 ,  RTAAACA_FREAC2_01 ,  HNF4ALPHA_Q6 ,  TFIIA_Q6 ,  STAT4_01 ,  TGANTCA_AP1_C ,  CREBP1CJUN_01 ,  CREB_Q4_01 ,  AREB6_02 ,  TGANNYRGCA_TCF11MAFG_01 ,  SYATTGTG_UNKNOWN ,  HFH1_01 ,  HP1SITEFACTOR_Q6 ,  ZIC3_01 ,  CTTTGA_LEF1_Q2 ,  CREB_Q3 ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  NFE2_01 ,  RYTGCNWTGGNR_UNKNOWN ,  FOXO3_01 ,  ATF_01 ,  RFX1_02 ,  STAT5B_01 ,  CAGGTG_E12_Q6 ,  AP1_01 ,  TATA_C ,  SP3_Q3 ,  YKACATTT_UNKNOWN ,  IRF_Q6 ,  GTTGNYNNRGNAAC_UNKNOWN ,  CTTTAAR_UNKNOWN ,  TGTTTGY_HNF3_Q6 ,  HFH8_01 ,  TTGTTT_FOXO4_01 ,  WGGAATGY_TEF1_Q6 ,  ATF1_Q6 ,  GTCNYYATGR_UNKNOWN ,  RYTGCNNRGNAAC_MIF1_01 ,  ZIC2_01 ,  TGACGTCA_ATF3_Q6 ,  GTGGGTGK_UNKNOWN ,  TTCYNRGAA_STAT5B_01 ,  TGATTTRY_GFI1_01 ,  WCAANNNYCAG_UNKNOWN ,  STAT5A_01 ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN ,  GTTRYCATRR_UNKNOWN ,  CREB_01 ,  FOXO4_02 ,  PAX4_01 ,  CCTNTMAGA_UNKNOWN ,  ATGTAGC_MIR221_MIR222

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

4q21.3

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