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QuickView for Josephin domain (biogroup)
- Description:
- The Josephin domain is an eukaryotic protein module of about 180 residues,which occurs in stand-alone form in Josephin-like proteins, and as an amino-terminal domain associated with two or three copies of the ubiquitin-interacting motif (UIM) in ataxin 3-like proteins. Josephin domain-containing proteins function as de-ubiquitination enzymes. Although it has originally been proposed that the Josephin domain could be an all-alpha helical domain distantly related to ENTH and VHS domains involved in membrane trafficking and regulatory adaptor function, it is now believed that it is a mainly alpha helical cysteine-protease domain predicted to be active against ubiquitin chains or related substrates.The Josephin domain contains two conserved histidines and one cysteine that is required for the ubiquitin protease activity and two ubiquitin-binding sites.Some proteins known to contain a Josephin domain are:Animal Machado-Joseph disease protein 1 (Ataxin 3). It interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription.Plant Machado-Joseph disease-like protein (MJD1a-like) (Ataxin 3 homologue).Mammalian Josephin 1 and 2.Drosophila melanogaster Josephin-like protein.Arabidopsis thaliana Josephin-like protein.
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