QuickView for KCND2;jsessionid=87B0FB3C37361706AF7BA5CD089E511C (gene)

Gene Symbol:

KCND2 Homo sapiens

Full name:

potassium voltage-gated channel subfamily D member 2

Synonyms:

KV4.2, RK5, potassium voltage-gated channel subfamily D member 2, potassium channel, voltage gated Shal related subfamily D, member 2, voltage-gated potassium channel subunit Kv4.2, voltage-sensitive potassium channel

Genomic Location:

Chr 7: 119700958-120177623

Description:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume....

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Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SP1_01 ,  ZIC1_01 ,  GGGATGC_MIR3245P ,  E2F1_Q4_01 ,  GCANCTGNY_MYOD_Q6 ,  NGFIC_01 ,  E2F_Q6_01 ,  ZIC3_01 ,  GTGCAAA_MIR507 ,  E2F1_Q4 ,  TCTAGAG_MIR517 ,  LEF1_Q6 ,  GCTTGAA_MIR498 ,  TTGGAGA_MIR5155P_MIR519E ,  ATGCTGG_MIR338 ,  E2F_Q6 ,  CAGGTG_E12_Q6 ,  GR_Q6 ,  E2F_Q4 ,  RRAGTTGT_UNKNOWN ,  ATTCTTT_MIR186 ,  GGGCGGR_SP1_Q6 ,  TAATAAT_MIR126 ,  E2F_03 ,  E2F_Q4_01 ,  NCX_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  GTGGTGA_MIR197 ,  ZIC2_01 ,  GTGGGTGK_UNKNOWN ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  CCANNAGRKGGC_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  EGR1_01 ,  AAAGGAT_MIR501 ,  KTGGYRSGAA_UNKNOWN ,  AAACCAC_MIR140 ,  E2F_Q3 ,  ACCTGTTG_UNKNOWN ,  E2F_Q3_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-324-5p ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-362 ,  Predicted Gene Targets for miR-363

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Cytogenetic Map:

7q31.31

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