QuickView for KCNMA1 (gene)

Gene Symbol:

KCNMA1 Homo sapiens

Full name:

potassium calcium-activated channel subfamily M alpha 1

Synonyms:

BKTM, CADEDS, KCa1.1, MaxiK, PNKD3, SAKCA, SLO, SLO-ALPHA, SLO1, bA205K10.1, hSlo, mSLO1, calcium-activated potassium channel subunit alpha-1, uncharacterized protein, BK channel alpha subunit, BKCA alpha subunit, big potassium channel alpha subunit, calcium-activated potassium channel, subfamily M subunit alpha-1, k(VCA)alpha, maxi-K channel HSLO, potassium channel, calcium activated large conductance subfamily M alpha, member 1, potassium large conductance calcium-activated channel, subfamily M, alpha member 1, slo homolog, slowpoke homolog, stretch-activated Kca channel

Genomic Location:

Chr 10: 78299366-79067583

Description:

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates t...

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MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  POU6F1_01 ,  SP1_01 ,  CCCACAT_MIR2993P ,  AAGCCAT_MIR135A_MIR135B ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  HEN1_01 ,  NKX3A_01 ,  CTTTGCA_MIR527 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  TGTGTGA_MIR377 ,  GTGACTT_MIR224 ,  TTTGTAG_MIR520D ,  WGTTNNNNNAAA_UNKNOWN ,  ATGTACA_MIR493 ,  FAC1_01 ,  E2A_Q2 ,  CYTAGCAAY_UNKNOWN ,  GCCATNTTG_YY1_Q6 ,  OSF2_Q6 ,  GGGAGGRR_MAZ_Q6 ,  TGTATGA_MIR4853P ,  ATCATGA_MIR433 ,  ATGCTGG_MIR338 ,  CAGGTG_E12_Q6 ,  CACCAGC_MIR138 ,  AP4_Q6 ,  LHX3_01 ,  ATTCTTT_MIR186 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  ACCAAAG_MIR9 ,  GGGCGGR_SP1_Q6 ,  GTATGAT_MIR154_MIR487 ,  E47_01 ,  AAAGACA_MIR511 ,  ACTGCAG_MIR173P ,  YCATTAA_UNKNOWN ,  GACAGGG_MIR339 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  AACATTC_MIR4093P ,  CEBP_C ,  CAAGGAT_MIR362 ,  AFP1_Q6 ,  HEN1_02 ,  AAGCACT_MIR520F ,  CAGCTG_AP4_Q5 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  GTTAAAG_MIR302B ,  CAATGCA_MIR33 ,  SP1_Q2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-328 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-362 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-485-3p ,  Predicted Gene Targets for miR-493-5p

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Cytogenetic Map:

10q22.3

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