QuickView for KCNN2;jsessionid=3D4D7746C6F752CE93DDD7660CDE2C41 (gene)

Gene Symbol:

KCNN2 Homo sapiens

Full name:

potassium calcium-activated channel subfamily N member 2

Synonyms:

KCa2.2, SK2, SKCA2, SKCa 2, hSK2, small conductance calcium-activated potassium channel protein 2, apamin-sensitive small-conductance Ca2+-activated potassium channel, potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, small conductance calcium-activated potassium channel 2

Genomic Location:

Chr 5: 113725915-113860096

Description:

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is...

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Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  GATA1_03 ,  MYOD_01 ,  HEN1_01 ,  CATTGTYY_SOX9_B1 ,  GCANCTGNY_MYOD_Q6 ,  NGFIC_01 ,  ATF4_Q2 ,  TAGCTTT_MIR9 ,  NFKAPPAB65_01 ,  TGAYRTCA_ATF3_Q6 ,  RYTGCNWTGGNR_UNKNOWN ,  STAT3_02 ,  SOX9_B1 ,  NFY_Q6_01 ,  ATF_01 ,  CAGGTG_E12_Q6 ,  E47_02 ,  AP4_Q6 ,  SP1_Q4_01 ,  EGR_Q6 ,  TGCGCANK_UNKNOWN ,  YGCANTGCR_UNKNOWN ,  ATF3_Q6 ,  GGGCGGR_SP1_Q6 ,  SPZ1_01 ,  AP2_Q3 ,  SP1_Q6 ,  GGCNNMSMYNTTG_UNKNOWN ,  AP2_Q6 ,  MTF1_Q4 ,  TTGTTT_FOXO4_01 ,  AP4_Q6_01 ,  CHOP_01 ,  HEN1_02 ,  SMAD4_Q6 ,  CTGCAGY_UNKNOWN ,  CTGYNNCTYTAA_UNKNOWN ,  T3R_Q6 ,  CREL_01 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  CCGNMNNTNACG_UNKNOWN ,  EGR1_01 ,  CAGCTG_AP4_Q5 ,  SRY_02 ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  PAX4_03 ,  TGACATY_UNKNOWN ,  ER_Q6 ,  CP2_01 ,  SP1_Q2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-140

Cytogenetic Map:

5q22.3

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