QuickView for KDM2B (gene)

Gene Symbol:

KDM2B Homo sapiens

Full name:

lysine demethylase 2B

Synonyms:

CXXC2, FBXL10, Fbl10, JHDM1B, PCCX2, lysine-specific demethylase 2B, CXXC-type zinc finger protein 2, F-box and leucine-rich repeat protein 10, F-box protein FBL10, F-box/LRR-repeat protein 10, JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein, [Histone-H3]-lysine-36 demethylase 1B, jmjC domain-containing histone demethylation protein 1B, jumonji C domain-containing histone demethylase 1B, lysine (K)-specific demethylase 2B, protein-containing CXXC domain 2

Genomic Location:

Chr 12: 120351282-120503272

Description:

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into ...

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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TCTGGAC_MIR198 ,  AGTTCTC_MIR146A_MIR146B ,  AACTGGA_MIR145 ,  ACATTCC_MIR1_MIR206 ,  GCTCTTG_MIR335 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  TTGCCAA_MIR182 ,  T3R_Q6 ,  ACCATTT_MIR522

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-146 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-544

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Cytogenetic Map:

12q24.31

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