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QuickView for KMO;jsessionid=450D57654DC4ABFCABB6F148EA7780BA (gene)


Gene Symbol:
KMO Homo sapiens Homo sapiens
Full name:
kynurenine 3-monooxygenase
Synonyms:
dJ317G22.1, kynurenine 3-monooxygenase, kynurenine 3-hydroxylase
Genomic Location:
Chr 1: 239762330-239825566
Description:
This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 1
1q43





GO Molecular Function

kynurenine 3-monooxygenase activity | oxidoreductase activity, acting on NAD(P)H | cofactor binding | nucleotide binding | flavin adenine dinucleotide binding | coenzyme binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | anion binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | ion binding | organic cyclic compound binding | FAD binding | NAD(P)H oxidase activity | oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor | heterocyclic compound binding | oxidoreductase activity | small molecule binding

GO Biological Process

kynurenine 3-monooxygenase activity | oxidoreductase activity, acting on NAD(P)H | response to cytokine | response to interleukin-1 | response to lipopolysaccharide | regulation of cellular localization | regulation of localization | positive regulation of neurotransmitter secretion | nicotinamide nucleotide biosynthetic process | benzene-containing compound metabolic process | regulation of neuron death | cellular amino acid catabolic process | cellular process | organic substance catabolic process | aromatic amino acid family metabolic process | dicarboxylic acid metabolic process | positive regulation of synaptic transmission | nucleotide metabolic process | tryptophan catabolic process | cellular amino acid metabolic process | cellular biogenic amine metabolic process | regulation of cellular process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | quinolinate metabolic process | positive regulation of glutamate secretion, neurotransmission | response to stimulus | response to salt stress | carboxylic acid catabolic process | response to stress | cellular nitrogen compound biosynthetic process | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | cofactor metabolic process | amine metabolic process | modulation of chemical synaptic transmission | cellular biosynthetic process | positive regulation of synaptic transmission, glutamatergic | nucleotide biosynthetic process | regulation of neurotransmitter levels | response to external biotic stimulus | nitrogen compound metabolic process | coenzyme biosynthetic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | regulation of synaptic transmission, glutamatergic | phosphorus metabolic process | positive regulation of glutamate secretion | amine catabolic process | NAD biosynthetic process | positive regulation of secretion | response to lipid | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | organophosphate metabolic process | cofactor biosynthetic process | small molecule metabolic process | nucleobase-containing small molecule metabolic process | cellular response to cytokine stimulus | cellular ketone metabolic process | biosynthetic process | response to osmotic stress | aromatic compound biosynthetic process | positive regulation of neuron death | regulation of glutamate secretion | L-kynurenine metabolic process | phosphate-containing compound metabolic process | response to bacterium | aromatic compound catabolic process | positive regulation of transport | quinolinate biosynthetic process | drug metabolic process | carboxylic acid metabolic process | pyridine nucleotide biosynthetic process | response to organic substance | metabolic process | kynurenine metabolic process | oxidation-reduction process | regulation of secretion | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | positive regulation of amino acid transport | positive regulation of ion transport | positive regulation of organic acid transport | aromatic amino acid family catabolic process | organonitrogen compound catabolic process | regulation of cell communication | organic acid metabolic process | response to biotic stimulus | regulation of ion transport | positive regulation of anion transport | NAD(P)H oxidase activity | nicotinamide nucleotide metabolic process | cellular response to interleukin-1 | NAD metabolic process | regulation of transport | heterocycle metabolic process | tryptophan metabolic process | regulation of anion transport | cellular biogenic amine catabolic process | oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor | cellular metabolic process | cellular response to organic substance | regulation of cell death | oxidoreductase activity | regulation of glutamate secretion, neurotransmission | response to other organism | positive regulation of signaling | regulation of signaling | regulation of neurotransmitter secretion

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | cell | organelle outer membrane | intrinsic component of membrane | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | organelle | mitochondrial outer membrane | mitochondrial envelope | outer membrane | mitochondrial membrane | cytosol | intracellular | membrane