QuickView for KRT1 (gene)

Gene Symbol:

KRT1 Homo sapiens

Full name:

keratin 1

Synonyms:

CK1, EHK, EHK1, EPPK, K1, KRT1A, NEPPK, keratin, type II cytoskeletal 1, 67 kDa cytokeratin, CK-1, cytokeratin 1, epidermolytic hyperkeratosis 1, hair alpha protein, keratin 1, type II, type-II keratin Kb1

Genomic Location:

Chr 12: 51354787-51360458

Description:

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granula...

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The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  CATTTCA_MIR203 ,  TATA_01 ,  CTTTGT_LEF1_Q2

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-203

Cytogenetic Map:

12q13.13

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