QuickView for Kv1.3 (gene)

Gene Symbol:

KCNA3 Homo sapiens

Full name:

potassium voltage-gated channel subfamily A member 3

Synonyms:

HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3, potassium voltage-gated channel subfamily A member 3, potassium channel 3, potassium channel, voltage gated shaker related subfamily A, member 3, potassium voltage-gated channel, shaker-related subfamily, member 3, type n potassium channel, voltage-gated K(+) channel HuKIII, voltage-gated potassium channel protein Kv1.3, voltage-gated potassium channel subunit Kv1.3

Genomic Location:

Chr 1: 111015833-111019178

Description:

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-rela...

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Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATGCAGT_MIR217 ,  ATAAGCT_MIR21 ,  TTANTCA_UNKNOWN ,  AAAGGGA_MIR204_MIR211 ,  YTATTTTNR_MEF2_02 ,  YATTNATC_UNKNOWN ,  PBX1_01 ,  TAAWWATAG_RSRFC4_Q2 ,  GGGAGGRR_MAZ_Q6 ,  TATA_C ,  STAT5A_03 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  CTTTAAR_UNKNOWN ,  TCCAGAT_MIR5165P ,  TGATTTRY_GFI1_01 ,  AAGCACA_MIR218

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-203

Cytogenetic Map:

1p13.3

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